辣椒素是從辣椒中提取的天然產(chǎn)品，可以激活瞬時受體電位香草酸亞型1（TRPV1）受體，它們的分子作用模式涉及重要的生理過程，這些過程是疼痛和內(nèi)源性調(diào)節(jié)機(jī)制的基礎(chǔ)。TRPV1和N-甲基-D-天冬氨酸（NMDA）受體均廣泛分布和表達(dá)于多種組織器官中，均具有較為復(fù)雜的生物學(xué)功能，這也預(yù)示著它們之間關(guān)系的探索，將為更多實驗研究提供理論基礎(chǔ)，并對新型藥物的研發(fā)及臨床應(yīng)用有著深遠(yuǎn)意義?？偨Y(jié)了TRPV1與背根神經(jīng)節(jié)NMDA受體之間相互作用與瑞芬太尼痛覺過敏的關(guān)系、與神經(jīng)毒性和神經(jīng)保護(hù)間的關(guān)系以及與抗焦慮樣效應(yīng)間的關(guān)系的研究進(jìn)展。

Capsaicin is a natural product extracted from Capsicum annuum L., which can activate the transient potential vanilloid receptor 1 (TRPV1) receptor. Its molecular mechanisms of action involve important physiological processes, which are the basis of pain and endogenous regulation mechanism. Transient receptor potential vanilloid type1 and N-methyl-D-aspartate (NMDA) receptors distribute and express widely in various tissues and organs, and they all have complex biological functions. This indicates that the exploration of the relationship between TRPV1 and NMDA receptors will provide a theoretical basis for more experimental studies. Also this has far-reaching significance for the development and clinical application of new drugs. This review summarizes the research progress on the interaction between TRPV1 and NMDA receptors whose relationship with remifentanil hyperalgesia, relationship with neurotoxicity and neuroprotection, and relationship with anti-anxiety-like effects.

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