a)為2.15 h−1。人口統(tǒng)計學(xué)因素(年齡、性別、體質(zhì)量等)及肝腎清除相關(guān)因素(肌酐清除率、膽紅素及白蛋白等)對卡培他濱的清除均無顯著性影響。結(jié)論 所得模型穩(wěn)定,能較好地擬合卡培他濱在腸癌患者的的群體藥動學(xué)特征,可用于臨床個體化給藥方案的制訂。;Objective To investigate the population pharmacokinetic characteristics of capecitabine and its possible influencing factors in colorectal cancer patients.Methods 56 colorectal cancer patients were chosen as the research objects. After a single dose of 0.6 g (0.15 g, 4 tablets, orally) of capecitabine tablets, blood samples were collected from multiple sites, the plasma concentration of capecitabine was determined by HPLC-MS/MS. The nonlinear mixed effect model and program (NONMEM) were used to analyze the data, the population pharmacokinetic model of capecitabine was established and its population pharmacokinetic parameters were obtained.Results The final model is one-compartment model with first order absorption and elimination. Population typical pharmacokinetic parameters of the model: clearance (CL) is 265 L/h, apparent volume of distribution (V) is 329 L, and the absorption rate constant (Ka) is 2.15 h−1. Demographic factors (age, gender, body weight, etc.) and liver kidney clearance related factors (creatinine clearance rate, bilirubin and albumin, etc.) have no significant effect on the clearance of capecitabine.Conclusion The model is stable and can well fit the population pharmacokinetic characteristics of capecitabine in Chinese patients with colorectal cancer, which can be used for developing a individualized administration scheme in clinical."/>

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首頁 > 過刊瀏覽>2021年第36卷第5期 >2021,36(5):873-877. DOI:10.7501/j.issn.1674-5515.2021.05.003
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卡培他濱在結(jié)直腸癌患者中的群體藥動學(xué)研究

Population pharmacokinetics of capecitabine in colorectal cancer patients

發(fā)布日期:2021-05-28