目的 探討金骨蓮膠囊聯(lián)合硫酸氨基葡萄糖膠囊和對乙酰氨基酚片治療膝骨性關(guān)節(jié)炎的臨床療效。方法 選取2019年1月—2020年1月商丘市第一人民醫(yī)院確診并接受治療的88例膝骨性關(guān)節(jié)炎患者，按照隨機數(shù)字表法分為對照組和治療組，每組各44例。對照組口服硫酸氨基葡萄糖膠囊，500 mg/次，3次/d；同時口服對乙酰氨基酚片，0.3 g/次，3次/d。治療組在對照組治療的基礎上口服金骨蓮膠囊，0.5 g/次，3次/d。兩組連續(xù)治療8周。觀察兩組臨床療效，比較兩組的骨關(guān)節(jié)指數(shù)（WOMAC）評分、Lysholm膝關(guān)節(jié)評分、疼痛程度和血清指標。結(jié)果 治療后，治療組的總有效率高于對照組，但差異無統(tǒng)計學意義。治療后，兩組WOMAC評分較治療前降低，Lysholm膝關(guān)節(jié)評分較治療前升高，差異有統(tǒng)計學意義（P<0.05），且治療組WOMAC評分低于對照組，Lysholm膝關(guān)節(jié)評分高于對照組，差異有統(tǒng)計學意義（P<0.05）。相較于治療前，治療4、8周兩組視覺模擬評分法（VAS）評分逐漸降低，差異有統(tǒng)計學意義（P<0.05），且治療4、8周治療組VAS評分均低于同期對照組，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組轉(zhuǎn)化生長因子β₁（TGF-β₁）水平較治療前升高，而血管內(nèi)皮生長因子（VEGF）水平較治療前降低，差異有統(tǒng)計學意義（P<0.05），且治療組TGF-β₁水平高于對照組，而VEGF水平低于對照組，差異有統(tǒng)計學意義（P<0.05）。結(jié)論 膝骨性關(guān)節(jié)炎患者在硫酸氨基葡萄糖膠囊和對乙酰氨基酚片治療的基礎上聯(lián)合使用金骨蓮膠囊可以促進膝關(guān)節(jié)功能恢復，改善膝骨性關(guān)節(jié)炎病情和減輕疼痛程度，提升抗炎效果，且安全性好。

Objective To explore the value of Jingulian Capsules combined with Glucosamine Sulfate Capsules and Paracetamol Tablets in treatment of knee joint osteoarthritis.Methods Patients (88 cases) with knee joint osteoarthritis in Shangqiu First People’s Hospital from January 2019 to January 2020 were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were po administered with Glucosamine Sulfate Capsules, 500 mg/time, three times daily. And patients in the control group were also po administered with Paracetamol Tablets, 0.3 g/time, three times daily. Patients in the treatment group were po administered with Jingulian Capsules on the basis of the control group, 0.5 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and WOMAC scores, Lysholm knee scores, pain degree, and serum indexes in two groups were compared.Results After treatment, the total effective rate of the treatment group was higher than that of the control group, but the difference was not statistically significant. After treatment, the WOMAC score in two groups were decreased, but the Lysholm knee score in two groups were increased, and the difference was statistically significant (P<0.05). After treatment, the WOMAC score in the treatment group was lower than that in the control group, while the Lysholm knee score in the treatment group was higher than that in the control group, and the difference was statistically significant (P<0.05). Compared with before treatment, the VAS score of two groups were decreased gradually at 4 and 8 weeks of treatment, and the difference was statistically significant (P<0.05). After treatment, the VAS score of the treatment group was lower than that of the control group at 4 and 8 weeks of treatment, and the difference was statistically significant (P<0.05). After treatment, the level of TGF-β₁ in two groups was higher than that before treatment, but the level of VEGF in two groups was lower than that before treatment, and the difference was statistically significant (P<0.05). The level of TGF-β₁ in the treatment group was higher than that in the control group, but the level of VEGF was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The combined use of Jingulian Capsules in treatment of patients with knee joint osteoarthritis on the basis of Glucosamine Sulfate Capsules and Paracetamol Tablets can improve the anti-inflammatory effect, promote the recovery of knee joint function, improve the condition of knee joint osteoarthritis and reduce the degree of pain, with good safety.

R977

河南省科技攻關(guān)計劃項目（Wjlx2019306）