目的 探討金振口服液聯(lián)合美洛西林鈉治療小兒急性支氣管炎的臨床療效。方法 回顧性分析2019年10月—2020年10月在濮陽市人民醫(yī)院治療的172例急性支氣管炎患兒的臨床資料，根據(jù)用藥的差別分為對照組和治療組，每組各86例。對照組靜脈滴注注射用美洛西林鈉，0.1～0.2 g/kg加入生理鹽水100 mL，1次/d。治療組在對照組的基礎(chǔ)上口服金振口服液，6個月～1歲5 mL/次，3次/d；2～3歲10 mL/次，2次/d；4～7歲10 mL/次，3次/d；8～12歲15 mL/次，3次/d。兩組患兒均治療7 d。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀消失時間，血清白細(xì)胞計數(shù)（WBC）、中性粒細(xì)胞百分比（NEUT）、淋巴細(xì)胞百分比（LYMPH）、超敏C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素-4（IL-4）、白細(xì)胞介素-8（IL-8）、降鈣素原（PCT）和白細(xì)胞介素-17A（IL-17A）水平。結(jié)果 治療后，治療組總有效率為98.84%，明顯高于對照組的82.56%（P<0.05）。治療后，治療組臨床癥狀改善時間明顯早于對照組（P<0.05）。治療后，兩組患兒血清WBC和NEUT顯著降低，但LYMPH水平顯著升高（P<0.05），且治療組改善最明顯（P<0.05）。治療后，兩組患兒血清hs-CRP、IL-4、IL-8、PCT、IL-17A水平均顯著下降，且治療組降低最明顯（P<0.05）。結(jié)論 注射用美洛西林鈉聯(lián)合金振口服液治療急性支氣管炎不僅可有效改善患兒臨床癥狀，還可顯著降低機(jī)體炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Jinzhen Oral Liquid combined with mezlocillin in treatment of children with acute bronchitis.Methods The clinical data of 172 children with acute bronchitis treated in Luohe Third People's Hospital from October 2019 to October 2020 were retrospectively analyzed and divided into control and treatment groups according to different treatments, and each group had 86 cases. Children in the control group were iv administered with Mezlocillin Sodium for injection, 0.1 — 0.2 g/kg added into normal saline 100 mL, once daily. Children in the treatment group were po administered with Jinzhen Oral Liquid on the basis of the control group, 5 mL/time for 6 months to 1 year old children, 10 mL/time for 2 — 3 years old children and twice daily, 10 mL/time for 4 — 7 years old children, 15 mL/time for 8 —12 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, the levels of serum WBC, NEUT, LYMPH, hs-CRP, IL-4, IL-8, PCT and IL-17A in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was 98.84%, which was significantly higher than 82.56% in the control group (P<0.05). After treatment, the disappearance time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the levels of serum WBC and NEUT were significantly decreased, but the level of LYMPH were significantly increased in two groups (P<0.05), and the improvement was the most obvious in the treatment group (P<0.05). After treatment, the serum levels of hs-CRP, IL-4, IL-8, PCT, and IL-17A were significantly decreased in two groups (P<0.05), especially in the treatment group (P<0.05).Conclusion Jinzhen Oral Liquid combined with mezlocillin in treatment of children with acute bronchitis can effectively improve the clinical symptoms and reduce the inflammatory response, which has a certain clinical application value.

R985