目的 分析2015—2020年蘭州大學(xué)第一醫(yī)院血流感染中鮑曼不動桿菌的臨床分布特征、抗菌藥物耐藥性變遷及感染的危險因素，為醫(yī)院感染的控制和臨床合理治療提供參考。方法 對2015—2020年蘭州大學(xué)第一醫(yī)院住院感染患者血培養(yǎng)陽性標(biāo)本中分離出的鮑曼不動桿菌菌株的科室分布、抗菌藥物耐藥性特點(diǎn)及危險因素進(jìn)行分析。結(jié)果 2015—2020年蘭州大學(xué)第一醫(yī)院住院感染患者血培養(yǎng)陽性標(biāo)本中共分離到104株鮑曼不動桿菌，主要來源于重癥監(jiān)護(hù)病房（ICU）、老年病科、血液科。鮑曼不動桿菌對多種抗菌藥物的耐藥率超過90%以上?；A(chǔ)疾病、入住ICU、侵襲性操作及使用抗生素成為影響鮑曼不動桿菌血流感染的危險因素。結(jié)論 血流感染中分離的鮑曼不動桿菌對常見抗菌藥物普遍耐藥，應(yīng)加強(qiáng)醫(yī)院感染控制，防止耐藥菌播散性。

Objective To analyze the clinical distribution characteristics of Acinetobacter baumannii in bloodstream infection, the changes of antimicrobial resistance and the risk factors of infection, so as to provide reference for the control and clinical rational treatment of nosocomial infection.Methods The department distribution, characteristics of antimicrobial resistance and risk factors of A. baumannii strains isolated from positive blood culture samples in the First Hospital of Lanzhou University from 2015 to 2020 were analyzed.Results 104 A. baumannii strains were mainly from ICU, geriatrics and hematology departments. Resistance rate of A. baumannii to antimicrobial drugs more than 90%. Underlying diseases, ICU admission, invasive procedures, and antibiotic use were risk factors for A. baumannii bloodstream infection.Conclusion A. baumannii isolated from bloodstream infection are generally resistant to common antimicrobial agents, so the control of nosocomial infection should be strengthened to prevent the spread of drug-resistant bacteria.

R969.3

蘭州大學(xué)第一醫(yī)院院內(nèi)基金資助項(xiàng)目（ldyyyn2017-05）