醋酸格拉默是美國(guó)食品藥品管理局（FDA）批準(zhǔn)用于治療復(fù)發(fā)–緩解型多發(fā)性硬化的藥物，能調(diào)節(jié)先天性和適應(yīng)性免疫調(diào)節(jié)系統(tǒng)，包括樹(shù)突狀細(xì)胞、單核細(xì)胞、B細(xì)胞和T調(diào)節(jié)細(xì)胞，從而中斷多發(fā)性硬化的發(fā)病過(guò)程。研究表明醋酸格拉默誘導(dǎo)的免疫細(xì)胞可以進(jìn)入炎癥部位釋放抗炎因子，緩解病理過(guò)程。除此之外，醋酸格拉默還具有神經(jīng)保護(hù)作用，包括促進(jìn)神經(jīng)營(yíng)養(yǎng)因子的釋放，促進(jìn)髓鞘再生，同時(shí)醋酸格拉默在阿爾茨海默病、帕金森病、抑郁癥等動(dòng)物模型上也證實(shí)了它的有效性。就醋酸格拉默作用機(jī)制及其在中樞神經(jīng)系統(tǒng)自身免疫疾病、退行性疾病中的作用進(jìn)行綜述。

Glatiramer acetate is a Food and Drug Administration (FDA) - approved drug for treatment of relapsing remitting multiple sclerosis, which modulates the innate and adaptive immune system, including dendritic cells, monocytes, B cells, and T cells, to interrupt the progression of multiple sclerosis. It has been reported that glatiramer acetate -induced immune cells can enter the site of inflammation and release anti-inflammatory factors, alleviating the pathological process. In addition, glatiramer acetate also has neuroprotective effects, including the release of neurotrophic factors and the regeneration of myelin. Besides this, glatiramer acetate promoted the immune-mediated neuroprotective response in several models of Alzheimer's disease, Parkinson's disease, and depression. This article is aimed at reviewing the mechanism of glatiramer acetate and its role in CNS autoimmune diseases and degenerative diseases.

R971

天津市科技計(jì)劃項(xiàng)目（16ZXMJSY00010）