苦參堿具有抗內(nèi)毒素性腎損傷、抗化療藥腎損傷、抗免疫性腎損傷、抗尿酸性腎病、抗輸尿管梗阻大鼠腎間質(zhì)纖維化和抗糖尿病腎病的作用?？鄥A腎臟保護(hù)作用的機(jī)制可能是下調(diào)脂多糖識(shí)別受體的表達(dá)、抑制JAK/STAT通路、抑制PI3K/AKT/mTOR通路和抑制ERK1/2通路，從而阻斷TGF-β1/Smad和NF-κB炎性信號(hào)通路，減輕腎臟炎癥反應(yīng)和細(xì)胞外基質(zhì)沉積，產(chǎn)生延緩腎臟纖維化的作用。

Matrine has the effects of antagonisms to endotoxic renal injury, chemotherapeutic renal injury, immunity renal injury, uric acid nephropathy, renal interstitial fibrosis after ureteral obstruction in rat, and diabetic renopathy. The mechanisms of renal protection of matrine may down-regulate the expression of pattern recognition receptors for LPS, to inhibit the pathways of JAK/ STAT, PI3K/AKT/mTOR, and ERK1/2, thus blocking the inflammatory signaling pathways of TGF-β1/Smad and NF-κB, and alleviating renal tissue inflammation and extracellular matrix deposit, and delaying fibrosis of kidney.

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