目的 觀察香橘丸聯(lián)合雙歧桿菌三聯(lián)活菌治療兒童胃腸功能性消化不良的臨床療效。方法 選擇2018年1月—2019年12月在鄂東醫(yī)療集團黃石市婦幼保健院兒童保健中心就診的243例兒童胃腸功能性消化不良患兒，根據(jù)隨機數(shù)字表法分為對照組（121例）和治療組（122例）。對照組飯后溫開水口服雙歧桿菌三聯(lián)活菌膠囊，2～5歲1粒/次，5歲以上2粒/次，3次/d。治療組在對照組治療基礎(chǔ)上口服小兒香橘丸，1丸/次，3次/d嚼服，也可分份吞服。兩組均連續(xù)治療40 d。觀察兩組的臨床療效，比較兩組營養(yǎng)及胃腸功能狀況指標、血清學(xué)指標的變化情況。結(jié)果 治療后，治療組總有效率92.6%，顯著高于對照組的87.6%（P<0.05）。治療后，兩組胃腸反應(yīng)面積（RA）、餐后功率比均顯著降低，但Kaup指數(shù)、體質(zhì)量指數(shù)顯著升高（P<0.05）；治療后，治療組營養(yǎng)及胃腸功能狀況指標改善優(yōu)于對照組（P<0.05）。治療后，兩組血清乙酰膽堿酯酶（AchE）、應(yīng)激蛋白（SP）均較治療前顯著升高，但膽囊收縮素（CCK）均顯著降低（P<0.05）；治療后，治療組AchE、SP均高于對照組，但CCK低于對照組（P<0.05）。結(jié)論 香橘丸聯(lián)合雙歧桿菌三聯(lián)活菌治療兒童胃腸功能性消化不良具有較好的臨床療效，可以調(diào)節(jié)胃腸功能狀況指標和AchE、CCK、SP水平，具有一定的臨床推廣應(yīng)用價值。

Objective To study the clinical effect of Xiangju Pills combined with bifidobacterium triplet living bacterium in treatment of functional gastrointestinal dyspepsia in children. Methods A total of 243 children with gastrointestinal functional dyspepsis who were admitted to the Child Health Care Center of Huangshi Maternal and Child Health-Care Hospital of Edong Medical Group from January 2018 to December 2019 were selected and divided into the control group (121 cases) and the treatment group (122 cases) according to the random number table method. Patients in the control group were po administered with Bifidobacterium Triplet Living Bacterium Capsules, 2-5 years old, 1 grain/time, over 5 years old, 2 grains/time, 3 times daily. Patients in the treatment group were po administered with Xiangju Pills on the basis of the control group, 1 pill/time, 3 times daily chewing, and they can also be divided into swallow. Both groups were treated for 40 d. The clinical efficacy of the two groups were observed, and the changes of nutrition, gastrointestinal function and serological indexes between the two groups were compare. Results After treatment, the total effective rate of treatment group was 92.6%, which was significantly higher than that of control group (87.6%) (P < 0.05). After treatment, gastrointestinal response area (RA) and postpranpranal power ratio were significantly decreased in two groups, but Kaup index and body mass index were significantly increased (P < 0.05). After treatment, the improvement of nutrition and gastrointestinal function in the treatment group was better than that in the control group (P < 0.05). After treatment, the serum acetylcholinesterase (AchE) and stress protein (SP) in two groups were significantly increased compared with before treatment, but the serum cholecystokinin (CCK) was significantly decreased (P < 0.05). After treatment, AchE and SP in treatment group were higher than those in control group, but CCK was lower than that in control group (P < 0.05). Conclusion Xiangju Pills combined with bifidobacterium triplet living bacterium has good clinical effect in treatment of functional gastrointestinal dyspepsia in children, and can regulate gastrointestinal function and AchE, CCK and SP levels, which has certain clinical application value.

R975;R985

湖北省衛(wèi)生健康委員會聯(lián)合基金項目（WJ2019H083）