目的 探討穿龍骨刺膠囊聯(lián)合艾瑞昔布治療膝骨關(guān)節(jié)炎的臨床效果。方法 選取2020年1月—2021年1月在鄭州大學(xué)第一附屬醫(yī)院治療的102例膝骨關(guān)節(jié)炎患者，根據(jù)用藥差別分為對照組和治療組，每組各51例。對照組口服艾瑞昔布片，0.1 g/次，2次/d；治療組在對照組基礎(chǔ)上口服穿龍骨刺片，4 g/次，3次/d。兩組均經(jīng)8周治療。觀察兩組的臨床療效，比較兩組臨床癥狀改善時間、相關(guān)評分和血清氧化應(yīng)激指標。結(jié)果 經(jīng)治療，治療組總有效率是98.04%，顯著高于對照組的82.35%（P<0.05）。經(jīng)治療，治療組膝關(guān)節(jié)疼痛、腫脹、活動受限改善時間明顯短于對照組（P<0.05）。經(jīng)治療，兩組VAS評分、WOMAC評分、ISOA評分均較治療前顯著降低，但Lysholm評分顯著升高（P<0.05）；且治療后治療組相關(guān)評分改善優(yōu)于對照組（P<0.05）。經(jīng)治療，兩組患者血清超氧化物歧化酶（SOD）顯著升高，但丙二醛（MDA）水平顯著降低（P<0.05）；治療后，治療組血清氧化應(yīng)激水平改善優(yōu)于對照組（P<0.05）。結(jié)論 穿龍骨刺膠囊聯(lián)合艾瑞昔布治療膝骨關(guān)節(jié)炎具有較好的臨床療效，可有效改善患者臨床癥狀，改善關(guān)節(jié)功能，抑制氧化應(yīng)激反應(yīng)，有著良好的臨床應(yīng)用價值。

Objective To investigate the effect of Chuanlong Guci Capsules combined with imrecoxib in treatment of knee osteoarthritis. Methods A total of 102 patients with knee osteoarthritis who were treated in the First Affiliated Hospital of Zhengzhou University from January 2020 to January 2021 were selected and divided into control group and treatment group according to medication difference, with 51 patients in each group. Patients in the control group were po administered with Imrecoxib Tablets, 0.1 g/time, twice daily. Patients in the treatment group were po administered with Chuanlong Guci Capsules on the basis of the control group, 4 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and clinical symptom improvement time, correlation score, and serum oxidative stress indexes were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 98.04%, which was significantly higher than that of the control group (82.35%, P < 0.05). After treatment, the improvement time of knee joint pain, swelling, and motion limitation in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, VAS score, WOMAC score, and ISOA score in both groups were significantly lower than before treatment, but Lysholm score was significantly increased (P < 0.05). After treatment, the improvement of related scores in the treatment group was better than that in the control group (P < 0.05). After treatment, the serum superoxide dismutase (SOD) level was significantly increased, but the serum malondialdehyde (MDA) level was significantly decreased (P < 0.05). After treatment, the improvement of serum oxidative stress level in treatment group was better than that in control group (P < 0.05). Conclusion Chuanlong Guci Capsules combined with imrecoxib has good clinical effect in treatment of knee osteoarthritis, and can effectively improve patients' clinical symptoms and joint function, also can inhibit oxidative stress reaction, which has good clinical application value.

R977

河南省醫(yī)學(xué)科技攻關(guān)計劃（聯(lián)合共建）項目（LHGJ20190176）