目的 探討復(fù)方樟腦乳膏聯(lián)合依巴斯汀治療兒童丘疹性蕁麻疹的臨床療效。方法 選取2018年9月—2020年9月在南陽市中心醫(yī)院治療的96例兒童丘疹性蕁麻疹患兒，根據(jù)隨機(jī)數(shù)字法分為對照組（48例）和治療組（48例）。對照組口服依巴斯汀片，10 mg/次，1次/d。治療組患兒在對照組的基礎(chǔ)上外用復(fù)方樟腦乳膏，2～3次/d。兩組患兒連續(xù)治療5 d。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀好轉(zhuǎn)時(shí)間，免疫球蛋白E（IgE）和淋巴毒素（LT）水平，血清白細(xì)胞介素-4（IL-4）、白細(xì)胞介素-17（IL-17）和γ-干擾素（IFN-γ）水平及不良反應(yīng)情況。結(jié)果 治療后，治療組患者總有效率明顯高于對照組（77.08%vs 97.92%，P<0.05）。治療后，治療組患者臨床癥狀好轉(zhuǎn)時(shí)間明顯短于對照組患者（P<0.05）。治療后，兩組免疫因子IgE、LT水平明顯降低（P<0.05），且治療組明顯低于對照組（P<0.05）。治療后，兩組血清IL-4、IL-17水平明顯下降，而IFN-γ水平明顯升高（P<0.05），且治療組血清IL-4、IL-17和IFN-γ水平明顯好于對照組（P<0.05）。治療組患者不良反應(yīng)發(fā)生率明顯低于對照組（P<0.05）。結(jié)論 復(fù)方樟腦乳膏與依巴斯汀聯(lián)合治療兒童丘疹性蕁麻疹效果顯著，可有效提高免疫能力，降低炎性反應(yīng)，安全有效。

Objective To investigate the efficacy of Compound Camphor Cream combined with ebastine in treatment of papular urticaria in children. Methods Children (96 cases) with papular urticaria in Nanyang Central Hospital from September 2018 to September 2020 were randomly divided into control (48 cases) and treatment (48 cases) groups. Children in the control group were po administered with Ebastine Tablets, 10 mg/time, once daily. Children in the treatment group were externally administered with Compound Camphor Cream, 2-3 times/d. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, the improvement time of clinical symptoms, the levels of immune IgE and LT factors, the levels of serum inflammatory IL-4, IL-17 and IFN-γfactors, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was significantly higher than that in the control group (77.08% vs 97.92%, P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the levels of immune factors IgE and LT in two groups were significantly decreased (P < 0.05), and the level of immune factors in the treatment group was significantly lower than that in the control group (P < 0.05). After treatment, the serum levels of IL-4 and IL-17 in two groups were significantly decreased, while the level of IFN-γ were significantly increased (P < 0.05), and the levels of serum IL-4, IL-17 and IFN-γ in the treatment group were significantly better than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion The combination of Compound Camphor Cream and ebastin is effective in treatment of papular urticaria in children, which can effectively improve immune ability, reduce inflammatory reaction with safe and effective.

R985