目的 研究艾附暖宮丸聯(lián)合間苯三酚治療原發(fā)性痛經的臨床療效。方法 選取2019年1月—2019年6月陜西省第四人民醫(yī)院收治的98例原發(fā)性痛經患者，隨機分為對照組和治療組，每組各49例。對照組肌內注射間苯三酚注射液，月經第1天注射，40 mg/次。治療組在對照組的基礎上口服艾附暖宮丸，6 g/次，3次/d，經前3 d開始服藥，連續(xù)口服14 d停藥。兩組治療3個月經周期。觀察兩組患者療效和隨訪結果，比較治療前后兩組患者疼痛強度VAS評分、疼痛持續(xù)時間、前列腺素F2α（PGF2α）、白細胞介素-6（IL-6）、白細胞介素-10（IL-10）和β-內啡肽水平及子宮動脈血流參數。結果 隨訪3個月后，治療組臨床有效率81.6%，明顯高于對照組的59.2%（P<0.05）。治療后、隨訪3個月后，治療組VAS評分和疼痛持續(xù)時間均顯著低于對照組（P<0.05）。治療后，兩組PGF2α、IL-6、IL-10水平均顯著降低，而β-內啡肽顯著升高（P<0.05），且治療組明顯好于對照組（P<0.05）。治療后，兩組患者子宮動脈血流參數顯著降低（P<0.05），且與對照組相比，治療組降低更明顯（P<0.05）。結論 艾附暖宮丸聯(lián)合間苯三酚治療原發(fā)性痛經不僅療效良好且作用時間持久，不良反應率低。

Objective to study the clinical effect of Aifu Nuangong Pills combined with phloroglucinol in treatment of primary dysmenorrhea. Methods Patients (98 cases) with primary dysmenorrhea in the Fourth People's Hospital of Shaanxi from January 2019 to June 2019 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were intramuscular injection administered with Phloroglucinol Injection on the first day of menstruation, 40 mg/time. Patients in the treatment group were po administered with Aifu Nuangong Pills 3 d before menstruation, 6 g/time, three times daily, and treated for 14 d. Patients in two groups were treated for 3 menstrual cycle. After treatment, the clinical efficacy and follow-up results was evaluated, the VAS scores and pain duration, PGF2α, IL-6, IL-10 and β-Endorphins levels, and uterine artery blood flow parameters in two groups before and after treatment were compared. Results After 3 months of follow-up, the clinical effective rate in the treatment group was 81.6%, which was significantly higher than 59.2% in the control group (P < 0.05). After treatment and 3 months of follow-up, the VAS score and pain duration in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of PGF2α, IL-6, and IL-10 in two groups were significantly decreased, while β-endorphin were significantly increased (P < 0.05), and which in the treatment group were significantly better than the control group (P < 0.05). After treatment, the uterine artery blood flow parameters in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Aifu Nuangong Pills combined with phloroglucinol in treatment of primary dysmenorrhea is not only effective and lasting, but also has a low rate of adverse reactions.

R984