目的 比較神效散散劑和巴布劑的透皮吸收效果。方法 采用HPLC法測(cè)定神效散散劑和巴布劑中血竭素、三七皂苷R₁。使用擴(kuò)散池裝置，以離體小鼠皮膚為屏障進(jìn)行體外透皮吸收研究，比較神效散巴布劑和散劑中血竭素、三七皂苷R1的累積滲透量、滲透速率。結(jié)果 神效散散劑和巴布劑中血竭素、三七皂苷R₁累積滲透量隨著時(shí)間的增加而增大，且兩種成分的累積滲透量：巴布劑>散劑；滲透速率：巴布劑>散劑。結(jié)論 與神效散散劑比較，神效散巴布劑具有更強(qiáng)的透皮吸收效果。

Objective To evaluate the transdermal absorption effect of Shenxiao Powder Cataplasm. Methods Dracorhodin and notoginseng saponin R₁ in Shenxiao Powder Cataplasm and Shenxiao Powder were determined. Diffusion cell device was used, and in vitro transdermal absorption was studies with isolated mouse skin as a barrier. The cumulative penetration and penetration rate of dracorhodin and notoginseng saponin R₁ in Shenxiao Powder Cataplasm and Shenxiao Powder were compared. Results The cumulative penetration of the two dosage forms were increased with the increase of time, and the cumulative penetration of the two main components was:cataplasm > powder; Penetration rate:cataplasm > powder. Conclusion Compared with Shenxiao Powder, Shenxiao Powder Cataplasm has stronger transdermal absorption.

R286.02

天津市中醫(yī)藥重點(diǎn)領(lǐng)域科研項(xiàng)目（2017007）；天津市中醫(yī)藥研究院附屬醫(yī)院院內(nèi)科研基金資助項(xiàng)目（2020004）