50歲年齡段患者居多;19例(76%)患者在用藥后1~2周出現(xiàn)黑舌或黑毛舌不良反應(yīng);在停用利奈唑胺并保持良好的口腔衛(wèi)生習(xí)慣后,黑舌或黑毛舌不良反應(yīng)癥狀好轉(zhuǎn)或消失。結(jié)論 利奈唑胺致黑舌或黑毛舌不良反應(yīng)為罕見(jiàn)的良性自限性不良反應(yīng),發(fā)病機(jī)制尚不明確,臨床醫(yī)師和藥師應(yīng)加強(qiáng)利奈唑胺的用藥監(jiān)測(cè)并做好解釋,以消除患者恐慌心理。;Objective To analyze the occurrence and clinical characteristics of black tongue or black hairy tongue adverse reaction induced by linezolid, and provide a reference for rational drug use. Methods To analyze the case reports of black tongue or black hairy tongue adverse reactions induced by linezolid were collected from Cochrane Library, PubMed, CNKI, Wanfang Journal Article Database, VIP Journal Database from January 2011 to January 2021. And the patients' gender, age, reasons for medication, usage and dosage, occurrence time of black tongue or black hairy tongue, clinical manifestations, treatment measures, clinical outcome time and other aspects were respectively analyzed. Results A total of 20 articles and 25 case reports of black tongue or black hairy tongue adverse reactions were identified. Among them, there were 17 males and 8 females, and the youngest was 5 years old and the oldest was 83 years old. Black tongue or black hairy tongue adverse reactions occurred in all ages, the majority of patients were ≤ 15 years old and >50 years old. 19 cases (76%) had black tongue or black hairy tongue adverse reactions about 1-2 weeks after medication. After withdrew the linezolid and kept good oral hygiene habits, the symptoms of the black tongue or black hairy tongue adverse reactions improved or disappeared. Conclusion The linezolid induced black tongue or black hairy tongue adverse reaction is a rare benign and self-limited adverse reaction, the exact pathogenesis is unclear. Clinicians and pharmacists should strengthen the monitoring of linezolid and do a good job of explanation,in order to eliminate the patients' panic psychology."/>