甲基蓮心堿是從睡蓮科植物蓮Nelumbo nucifera成熟種子的胚芽中提取出的一種雙芐基異喹啉類生物堿，具有抗動(dòng)脈粥樣硬化、抗高血壓、抗血栓、抗糖尿病血管病變和血管保護(hù)作用、抗心律失常等作用。心血管疾病是全球發(fā)病率和死亡率最高的一類疾病，包括心絞痛、高血壓、高血脂、動(dòng)脈粥樣硬化。近年來(lái)，有研究表明甲基蓮心堿對(duì)心血管疾病防治具有療效好、副作用低的特點(diǎn)。對(duì)甲基蓮心堿在心血管疾病中的藥理作用及其機(jī)制進(jìn)行綜述，為甲基蓮心堿的藥物研發(fā)和臨床應(yīng)用提供參考。

Neferine, a bisbenzyl isoquinoline alkaloid, was extracted from the seed embryo of Nelumbo nucifera Gaertn. It has multiple pharmacological effects, including anti-atherosclerosis, anti-hypertension, anti-thrombosis, anti-diabetic vascular disease and vascular protection, and anti-arrhythmic effect. Cardiovascular diseases are the highest morbidity and mortality in the world, including angina pectoris, hypertension, hyperlipidemia, and atherosclerosis. Recently, more and more studies have shown that neferine has the characteristics of good curative effect and low side effects in the prevention and treatment of cardiovascular diseases. This article reviews the pharmacological effects and mechanisms of neferine in cardiovascular diseases, and provides references for the drug development and clinical application of neferine.

R285;R972

江西省教育廳科學(xué)技術(shù)研究項(xiàng)目（GJJ180809）；贛南醫(yī)學(xué)院科研課題（YB201801）；心腦血管疾病防治教育重點(diǎn)實(shí)驗(yàn)室開(kāi)放課題（XN202025）