目的 探討腦安顆粒聯(lián)合阿司匹林腸溶片治療急性腦梗死的臨床療效。方法 選取2018年6月—2021年2月河南理工大學(xué)第一附屬醫(yī)院收治的68例急性腦梗死患者作為研究對象，根據(jù)隨機(jī)數(shù)字表法將68例患者分為對照組和治療組，每組各包括34例。對照組口服阿司匹林腸溶片，100 mg/次，1次/d。治療組在對照組基礎(chǔ)上口服腦安顆粒，1.2 g/次，2次/d。兩組患者連續(xù)治療4周。觀察兩組的臨床療效，比較兩組神經(jīng)功能、血液流變學(xué)和血清因子水平。結(jié)果 治療后，治療組患者的總有效率為94.12%，對照組的總有效率為76.47%，組間對比差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的美國國立衛(wèi)生卒中量表（NIHSS）評分顯著降低（P<0.05），治療組NIHSS評分比對照組降低更明顯（P<0.05）。治療后，兩組的纖維蛋白原、血小板聚集性、血漿比黏度顯著降低（P<0.05）；治療后，治療組的纖維蛋白原、血小板聚集性、血漿比黏度低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的正五聚體蛋白-3（PTX-3）、血小板活化因子（PAF）、缺血修飾白蛋白（IMA）水平顯著降低（P<0.05）；治療組的PTX-3、PAF、IMA水平低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 腦安顆粒聯(lián)合阿司匹林腸溶片治療急性腦梗死的療效確切，可改善血液流變學(xué)和神經(jīng)功能，減輕炎癥反應(yīng)，且安全性良好。

Objective To investigate the clinical efficacy of Naoan Granules combined with Aspirin Enteric-Coated Tablets in treatment of acute cerebral infarction. Methods Patients (68 cases) with acute cerebral infarction in the First Affiliated Hospital of Henan University of Technology from June 2018 to February 2021 were randomly divided into control and treatment groups, and each group had 34 cases. Patients in the control group were po administered with Aspirin Enteric-coated Tablets, 100 mg/time, once daily. Patients in the treatment group were po administered with Naoan Granules on the basis of the control group, 1.2 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and nerve function, hemorheology, and serum factors in two groups were compared. Results After treatment, the total effective rate was 94.12% in the treatment group, and 76.47% in the control group, and there was significant difference between two groups (P < 0.05). After treatment, the NIHSS score of two groups were significantly decreased (P < 0.05), and the NIHSS score of the treatment group were significantly lower than that of the control group (P < 0.05). After treatment, the fibrinogen, platelet aggregation, and plasma specific viscosity in two groups were significantly decreased (P < 0.05). After treatment, the fibrinogen, platelet aggregation, and plasma specific viscosity in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of PTX-3, PAF, and IMA in group were significantly lower than those in the control group (P < 0.05). Conclusion Naoan Granules combined with Aspirin Enteric-Coated Tablets has clinical curative effect in treatment of acute cerebral infarction, can improve hemorheology and nerve function, reduce inflammatory reaction, with good safety.

R971

河南省醫(yī)學(xué)科技攻關(guān)計劃項目（2018020852）