目的 探討芪骨膠囊聯(lián)合阿侖膦酸鈉維D3治療老年骨質(zhì)疏松患者的安全性與有效性。方法 選取2019年6月—2020年12月在空軍軍醫(yī)大學(xué)第二附屬醫(yī)院診治的94例老年骨質(zhì)疏松患者，按照入組順序分成對(duì)照組和治療組，每組各47例。對(duì)照組口服阿侖膦酸鈉維D3片，1片/次，1次/周；治療組患者在對(duì)照組的基礎(chǔ)上口服芪骨膠囊，3粒/次，1次/d。兩組患者治療25周。觀察兩組患者臨床療效，比較治療前后兩組患者NRS評(píng)分、Oswestry功能障礙指數(shù)和生活質(zhì)量評(píng)分，及血清耐酒石酸酸性磷酸酶5b（TRACP-5b）、Ⅰ型膠原交聯(lián)氨基末端肽（NTX）和Ⅰ型原膠原氨基末端原肽（PINP）水平。結(jié)果 治療后，對(duì)照組總有效率顯著低于治療組（82.98%vs 95.74%，P<0.05）。治療后，兩組NRS評(píng)分和Oswestry功能障礙指數(shù)顯著下降，而生活質(zhì)量評(píng)分顯著升高（P<0.05），且治療組各指標(biāo)比對(duì)照組改善更顯著（P<0.05）。治療后，兩組患者血清TRACP-5b和NTX水平顯著降低，而PINP水平顯著升高（P<0.05），且治療組相對(duì)于對(duì)照組改善更顯著（P<0.05）。結(jié)論 芪骨膠囊聯(lián)合阿侖膦酸鈉維D3治療老年骨質(zhì)疏松療效確切，可顯著改善患者疼痛癥狀和生活質(zhì)量，平衡骨轉(zhuǎn)換和骨形成水平。

Objective To investigate the safety and effectiveness of Qigu Capsules combined with alendronate sodium and vitamin D3 in treatment of senile osteoporosis. Methods Patients (94 cases) with senile osteoporosis in the Second Affiliated Hospital of PLA Air Force Military Medical University from July 2019 to December 2020 were divided into control and treatment groups according the order of entry, and each group had 47 cases. Patients in the control group were po administered with Alendronate Sodium and Vitamin D3 Tablets, 1 tablet/time, once weekly. Patients in the treatment group were po administered with Qigu Capsules, 3 grains/time, once daily. Patients in two groups were treated for 25 weeks. After treatment, the clinical efficacy was evaluated, the NRS score, Oswestry dysfunction index and quality of life score, the levels of serum TRACP-5b, NTX, and PINP in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the control group was significantly lower than that of the treatment group (82.98% vs 95.74%, P < 0.05). After treatment, the NRS score and Oswestry dysfunction index in two groups were significantly decreased, while the quality of life score was significantly increased (P < 0.05), and the improvement of each index in the treatment group was more significant than that in the control group (P < 0.05). After treatment, the serum levels of TRACP-5b and NTX in two groups were significantly decreased, while the level of PINP was significantly increased (P < 0.05), and the treatment group improved more significantly than the control group (P < 0.05). Conclusion The curative effect of Qigu Capsules combined with alendronate sodium and vitamin D3 in treatment of senile osteoporosis is definite, and can significantly improve the pain symptoms and quality of life, and balance the level of bone turnover and bone formation.

R977

陜西省重點(diǎn)研發(fā)計(jì)劃項(xiàng)目（2017SF-223）