目的 探討通迪膠囊聯(lián)合雙氯芬酸二乙胺乳膠劑治療膝關(guān)節(jié)軟組織損傷的臨床療效。方法 選取2019年3月—2021年7月在河南省洛陽(yáng)正骨醫(yī)院就診的68例膝關(guān)節(jié)軟組織損傷患者，按照隨機(jī)數(shù)字表法將全部患者分為對(duì)照組和治療組，每組各有34例。對(duì)照組患處根據(jù)受損面積涂抹雙氯芬酸二乙胺乳膠劑，3次/d。治療組患者在對(duì)照組基礎(chǔ)上口服通迪膠囊，6粒/次，3次/d。兩組患者連續(xù)治療14 d。觀察兩組的療效，比較兩組的視覺(jué)模擬評(píng)分法（VAS）評(píng)分、膝關(guān)節(jié)功能量表（Lysholm）評(píng)分、WHO生活質(zhì)量量表（WHOQOL-BREF）評(píng)分以及血清中白細(xì)胞介素-6（IL-6）、C-反應(yīng)蛋白（CRP）水平。結(jié)果 治療后，治療組的總有效率為94.12%，比對(duì)照組總有效率（76.47%）高，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的VAS評(píng)分顯著降低，Lysholm評(píng)分、WHOQOL-BREF評(píng)分顯著提高（P<0.05），治療組VAS評(píng)分低于對(duì)照組，Lysholm評(píng)分、WHOQOL-BREF評(píng)分高于對(duì)照組（P<0.05）。治療后，兩組的血清IL-6、CRP水平明顯減少，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療組的IL-6、CRP水平明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 通迪膠囊聯(lián)合雙氯芬酸二乙胺乳膠劑治療膝關(guān)節(jié)軟組織損傷具有較好的療效，能減輕疼痛程度，改善患者的關(guān)節(jié)功能和生活質(zhì)量，調(diào)節(jié)炎癥因子水平，安全性良好。

Objective To investigate the clinical study of Tongdi Capsules combined with Diclofenac Diethylamine Emulgel in treatment of knee soft tissue injury. Methods Patients (68 cases) with knee soft tissue injury in Luoyang Orthopedic-Traumatological Hospital of Henan Province from March 2019 to July 2021 were randomly divided into control and treatment groups, and each group had 34 cases. Patients in the control group were given administered with Diclofenac Diethylamine Emulgel according to the damaged area, three times daily. Patients in the treatment group were po administered with Tongdi Capsules on the basis of the control group, 6 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and VAS scores, Lysholm scores, WHOQOL-BREF scores, and the levels of IL-6 and CRP in two groups were compared. Results After treatment, the total effective rate of the treatment group (94.12%) was higher than that of the control group (76.47%) (P < 0.05). After treatment, the VAS score of two groups were significantly decreased, but the Lysholm scores and WHOQOL-BREF scores of two groups were significantly increased (P < 0.05). The VAS score of the treatment group was lower than that of the control group, but the Lysholm score and WHOQOL-BREF score of the treatment group were higher than those of the control group (P < 0.05). After treatment, the levels of IL-6 and CRP in two groups were significantly decreased (P < 0.05), and the levels of IL-6 and CRP in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Tongdi Capsules combined with Diclofenac Diethylamine Emulgel has clinical curative effect in treatment of knee soft tissue injury, can reduce the degree of pain, improve the joint function and quality of life of patients, regulate the level of inflammatory factors, with good safety.

R977

河南省中醫(yī)藥科學(xué)研究專項(xiàng)課題（20-21ZY1059）