目的 觀察小兒肺熱咳喘顆粒治療小兒支氣管哮喘的臨床療效和安全性。方法 選擇2016年7月—2018年4月在丹東市中醫(yī)院110例小兒支氣管哮喘患兒為研究對象，隨機分成對照組和治療組，每組各55例。兩組均給予基礎治療。對照組口服小兒肺熱咳喘顆粒模擬劑，1～2歲1袋/次，3次/d；3～5歲1袋/次，4次/d。治療組口服小兒肺熱咳喘顆粒，1～2歲1袋/次，3次/d；3～5歲1袋/次，4次/d。兩組患兒連續(xù)服藥28 d。觀察兩組患兒臨床療效，比較治療前后兩組患兒肺功能指標用力肺活量（FVC）、第1秒用力呼氣量（FEV1）、FEV1占FVC比值（FEV1/FVC）、最大呼氣流速（PEF）、肺活量（VC）及中醫(yī)證候療效。結果 治療后，治療組患兒總有效率為89.09%，明顯高于對照組的72.73%（P<0.05）。治療后，治療組患兒FEV1、FEV1/FVC、PEF、VC均明顯高于對照組（P<0.05）。治療后，治療組患兒中醫(yī)證候有效率在14、28 d分別為70.91%、92.72%；對照組患兒分別為50.91%和78.18%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 小兒肺熱咳喘顆粒治療小兒支氣管哮喘患兒臨床效果好且未觀察到不良反應，具有一定的臨床推廣應用價值。

Objective To observe the efficacy and safety of Xiaoer Feire Kechuan Granules in treatment of children with bronchial asthma. Methods Children (110 cases) with bronchial asthma in Dandong Hospital of Traditional Chinese Medicine from July 2016 to April 2018 were randomly divided into control and treatment groups, and each group had 55 cases. Children in two groups were administered with basic treatment. Children in the control group were po administered with Xiaoer Feire Kechuan Granules simulator, 1 bag/time for 1-2 years old children, three times daily, 1 bag/time for 3-5 years old children, four times daily. Children in the treatment group were po administered with Xiaoer Feire Kechuan Granules, 1 bag/time for 1-2 years old children, three times daily, 1 bag/time for 3-5 years old children, four times daily. Children in two groups were treated for 28 d. After treatment, the clinical efficacy was evaluated, the pulmonary function indexes of FEV1, FEV1/FVC, PEF and VC, and the curative effect of TCM syndromes in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was 89.09%, which was significantly higher than 72.73% in the control group (P < 0.05). After treatment, the levels of FEV1, FEV1/FVC, PEF and VC in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the effective rate of TCM syndrome in the treatment group was 70.91% and 92.72% on 14 d and 28 d, while those in the control group was 50.91% and 78.18%, respectively, and the difference between the two groups was statistically significant (P < 0.05). Conclusion Xiaoer Feirre Kechuan Granules has a good clinical effect in the treatment of children with bronchial asthma and no adverse reactions were observed, which has a certain clinical application value.

R974;R985