目的 探討加巴噴丁聯(lián)合玻璃酸鈉對(duì)膝骨關(guān)節(jié)炎患者疼痛及血清炎癥因子的影響。方法 選擇2018年6月—2020年9月于新鄉(xiāng)醫(yī)學(xué)院第三附屬醫(yī)院住院治療的115例膝骨關(guān)節(jié)炎患者為觀察對(duì)象，按照隨機(jī)數(shù)字表法分為對(duì)照組（n=57）和治療組（n=58）。對(duì)照組膝關(guān)節(jié)腔注射玻璃酸鈉注射液，2 mL/次，1次/周。治療組患者在對(duì)照組基礎(chǔ)上口服加巴噴丁片，300 mg/次，3次/d。兩組均治療4周。觀察兩組的臨床療效，比較兩組視覺模擬（VAS）評(píng)分、炎癥因子水平、西安大略和麥克馬斯特大學(xué)骨關(guān)節(jié)炎指數(shù)（WOMAC）評(píng)分、健康狀況調(diào)查簡(jiǎn)表（SF-36）評(píng)分。結(jié)果 治療后，治療組總有效率是91.38%，顯著高于對(duì)照組的73.68%（P<0.05）。與治療前比較，兩組患者治療1、2、4周VAS評(píng)分、WOMAC評(píng)分均顯著降低，但SF-36評(píng)分顯著升高（P<0.05）；且治療后治療組相關(guān)評(píng)分改善優(yōu)于對(duì)照組同期（P<0.05）。與治療前比較，兩組患者治療1、2、4周血清白細(xì)胞介素-1β（IL-1β）和腫瘤壞死因子-α（TNF-α）水平均較治療前顯著降低（P<0.05）；且治療后，治療組血清炎癥因子水平顯著低于對(duì)照組同期（P<0.05）。結(jié)論 加巴噴丁聯(lián)合玻璃酸鈉可顯著緩解膝骨關(guān)節(jié)炎患者疼痛癥狀，減輕炎癥反應(yīng)，改善膝關(guān)節(jié)功能，提高生活質(zhì)量。

Objective To investigate the effect of gabapentin combined with sodium hyaluronate on pain and serum inflammatory factors in patients with knee osteoarthritis. Methods 115 Patients with knee osteoarthritis hospitalized in the Third Affiliated Hospital of Xinxiang Medical University from June 2018 to September 2020 were collected and divided into control group (n=57) and treatment group (n=58) according to random number table method. The control group received Sodium Hyaluronate Injection, 2 mL/time, once a week, 4 weeks as a course of treatment. Patients in the treatment group were po administered with Gabapentin Tablets on the basis of the control group, 300 mg/time, 3 times daily, 4 weeks as a course of treatment. After treatment, the clinical efficacy was evaluated, and VAS score, inflammatory factor levels, WOMAC score and SF-36 score were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 91.38%, significantly higher than that of the control group (73.68%) (P<0.05). Compared with before treatment, VAS score and WOMAC score were significantly decreased at 1, 2, and 4 weeks after treatment, but SF-36 score was significantly increased in two groups (P<0.05). The improvement of the correlation score in the treatment group was better than that in the control group (P<0.05). Compared with before treatment, serum interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) levels in two groups were significantly decreased at 1, 2, and 4 weeks after treatment (P<0.05). After treatment, the level of serum inflammatory factors in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Gabapentin combined with sodium hyaluronate can significantly relieve pain symptoms in patients with knee osteoarthritis, and can reduce inflammation, improve knee function and quality of life.

R982

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃（聯(lián)合共建）項(xiàng)目（LOGO20190492）