目的 探討酪酸梭菌二聯(lián)活菌散聯(lián)合復(fù)方胃蛋白酶顆粒治療小兒功能性消化不良的臨床療效。方法 回顧性分析2020年2月—2021年2月在鄭州大學(xué)附屬兒童醫(yī)院診治的104例功能性消化不良患兒的臨床資料，根據(jù)就診順序分為對照組和治療組，每組各52例。對照組口服復(fù)方胃蛋白酶顆粒，10 g/次，3次/d；治療組在對照組基礎(chǔ)上口服酪酸梭菌二聯(lián)活菌散，500 mg/次，2次/d。兩組患兒治療2周。觀察兩組患兒臨床療效，比較治療前后兩組患兒FDDQL評分、臨床癥狀評分、GOSS評分，血清胃腸激素和腦腸肽水平，胃電圖指標(biāo)。結(jié)果 經(jīng)治療，對照組和治療組的臨床有效率分別為84.62%、98.08%（P<0.05）。經(jīng)治療，兩組FDDQL評分明顯升高，而臨床癥狀評分和GOSS評分明顯下降（P<0.05），且治療組患兒評分明顯好于對照組（P<0.05）。經(jīng)治療，兩組患兒血清胃動素（MTL）和神經(jīng)肽Y（NPY）水平明顯升高，而胃泌素（GAS）、生長抑素（SS）和血管活性腸肽（VIP）水平均明顯下降（P<0.05），且治療組患兒血清胃腸激素、腦腸肽水平明顯好于對照組（P<0.05）。經(jīng)治療，兩組患兒平均收縮波頻率（MFC）、收縮波幅值（AC）均明顯升高（P<0.05），且治療組患兒胃電圖指標(biāo)水平明顯高于對照組患兒（P<0.05）。結(jié)論 酪酸梭菌二聯(lián)活菌散聯(lián)合復(fù)方胃蛋白酶顆粒治療小兒功能性消化不良可有效改善患兒臨床癥狀，促進(jìn)機(jī)體胃腸激素、腦腸肽分泌的改善，有利于胃電節(jié)律和生活質(zhì)量的改善。

Objective To investigate the clinical efficacy of Combined Clostridium Butyricum and Bifidobacterium Powders combined with Compound Saccharated Pepsin Granules in treatment of children with functional dyspepsia. Methods The clinical data of 104 children with functional dyspepsia diagnosed and treated in Children's Hospital Affiliated to Zhengzhou University from February 2020 to February 2021 were divided into control and treatment groups according to visiting order, and each group had 52 cases. Patients in the control group were po administered with Compound Saccharated Pepsin Granules, 10 g/time, three times daily. Patients in the treatment group were po administered with Combined Clostridium Butyricum and Bifidobacterium Powders, Live, 500 mg/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical evaluation was evaluated, the FDDQL scores, clinical symptom scores and GOSS scores, serum gastrointestinal hormone and brain-gut peptide levels, and the level of electrogastrogram indexes in two groups before and after treatment were compared. Results After treatment, the clinical effective rates of the control group and the treatment group were 84.62% and 98.08% respectively (P<0.05). After treatment, the FDDQL score were significantly increased, while the clinical symptom score and GOSS score were significantly decreased in two groups (P<0.05), and the scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the levels of serum MTL and NPY were significantly increased, while the levels of GAS, SS and VIP were significantly decreased in two groups (P<0.05), and the levels of serum gastrointestinal hormone and brain-gut peptide in the treatment group were significantly better than those in the control group (P<0.05). After treatment, MFC and AC were significantly increased in two groups, and the level of electrogastrogram in the treatment group was significantly higher than that in the control group (P<0.05). Conclusion Combined Clostridium Butyricum and Bifidobacterium Powders, Live combined with Compound Saccharated Pepsin Granules in treatment of children with functional dyspepsia can effectively improve the clinical symptoms of children, promote the secretion of gastrointestinal hormones and brain-gut peptides, and be beneficial to the improvement of gastroelectric rhythm and quality of life.

R985

河南省醫(yī)學(xué)科技攻關(guān)項(xiàng)目（2018020680）