目的 分析帶量采購對抗抑郁藥原研藥和仿制藥使用情況的影響，為政策制定和醫(yī)院藥事管理提供參考。方法 采用藥物經(jīng)濟(jì)學(xué)方法對帶量采購實施前后漯河市中心醫(yī)院西城分院抗抑郁藥的使用數(shù)量、使用金額、用藥頻度（DDDs）、日均費用（DDC）、仿制藥替代率、費用節(jié)省等進(jìn)行分析。結(jié)果 帶量采購政策實施后抗抑郁藥中仿制藥使用數(shù)量明顯增加，而使用金額卻降低了，醫(yī)療費用有一定節(jié)省，仿制藥替代率還有提升空間。結(jié)論 此次帶量采購政策落地1年后，一定程度上解決了藥品價格虛高問題，切實降低了部分患者的用藥負(fù)擔(dān)。

Objective To analyze the influence of the pharmaceutical procurement with target quantity on the use of original and generic antidepressant drugs, and to provide references for policy formulation and hospital pharmaceutical administration. Methods Pharmacoeconomic method was used to analyze the sales amount, sales volume, DDDs, DDC, replacement rate of generic drugs and cost saving of antidepressants in a hospital of one years before and after the implementation of procuring with target quantity. Results After the implementation of the procuring with target quantity policy, the usage volume of generic drugs in antidepressants was increased, while the amount of generic drugs was decreased. So the cost was saved. There was still room for improvement in the replacement rate of generic drugs. Conclusion After the implementation of the procuring with target quantity policy for one year, the problem of artificially high drug prices is solved to some extent and the drug burden of some patients was effectively reduced.

R952