[關(guān)鍵詞]
[摘要]
藥物的心臟毒性研究已經(jīng)成為藥物臨床安全性評價的一項重要內(nèi)容。隨著上市藥物的逐步增多，心臟毒性藥物不良反應(yīng)的報道也呈現(xiàn)上升趨勢，近年來藥物心臟毒性評價的研究也越來越受到國內(nèi)外學(xué)者的青睞，但是藥物心臟毒性評價還沒有建立一套客觀準(zhǔn)確的體外方法。擬全面歸納了心臟毒性藥物的分類，整合了藥物心臟毒性評價的方法，并對藥物心臟毒性評價新技術(shù)進(jìn)行了介紹，為心臟毒性藥物的安全性評價工作的開展提供了思路。
[Key word]
[Abstract]
The study of drug cardiotoxicity has become an important part of the clinical safety evaluation of drugs. With the gradual increase of marketed drugs, the reports of adverse reactions of cardiotoxic drugs have also shown an upward trend. In recent years, research on drug cardiotoxicity evaluation has also been favored by scholars at home and abroad. However, an objective set of drug cardiotoxicity evaluation has not yet been established. This article comprehensively summarizes the classification of cardiotoxic drugs, integrates the methods of drug cardiotoxicity evaluation, and introduces new technologies for drug cardiotoxicity evaluation, which provides ideas for the development of the safety evaluation of cardiotoxic drugs.
[中圖分類號]
R972
[基金項目]
國家自然科學(xué)基金青年科學(xué)基金項目（81700183）；天津醫(yī)科大學(xué)腫瘤醫(yī)院科研項目（1810）
