[關(guān)鍵詞]
[摘要]
目的 觀察膚痔清軟膏聯(lián)合口服鹽酸左西替利嗪片治療慢性肛周濕疹的臨床療效。方法 選擇天津市寧河區(qū)醫(yī)院在2018年3月—2020年6月收治的102例慢性肛周濕疹患者,隨機(jī)分為對(duì)照組(51例)和治療組(51例)。對(duì)照組患者睡前口服鹽酸左西替利嗪片,5 mg/次,1次/d。治療組在對(duì)照組基礎(chǔ)上患處涂抹膚痔清軟膏,早晚各1次。兩組連續(xù)治療12周。觀察兩組患者臨床療效,比較治療前后兩組患者炎癥因子水平、肛周瘙癢程度、皮損面積及形態(tài)、生活質(zhì)量指數(shù)和復(fù)發(fā)率。結(jié)果 治療后,治療組患者臨床有效率明顯高于對(duì)照組(P<0.05)。治療后,兩組患者腫瘤壞死因子-α(TNF-α)和白細(xì)胞介素-6(IL-6)明顯下降,而γ干擾素(IFN-γ)明顯升高(P<0.05),且治療組IL-6、TNF-α和IFN-γ明顯好于對(duì)照組(P<0.05)。治療后,兩組患者皮損面積及形態(tài)、肛周瘙癢程度、生活質(zhì)量指數(shù)評(píng)分明顯下降(P<0.05),且治療組患者顯著低于對(duì)照組(P<0.05)。治療后,治療組3、6個(gè)月的復(fù)發(fā)率明顯低于對(duì)照組(P<0.05)。結(jié)論 膚痔清軟膏聯(lián)合口服鹽酸左西替利嗪片治療慢性肛周濕疹,可有效改善其臨床癥狀,減少?gòu)?fù)發(fā)率,降低炎癥因子水平,療效可靠。
[Key word]
[Abstract]
Objective To observe the efficacy of Fuzhiqing Ointment combined with levocetirizine in treatment of chronic perianal eczema.Methods Patients (102 cases) with chronic perianal eczema in Ninghe District Hospital from March 2018 to June 2020 were randomly divided into control (51 cases) and treatment (51 cases) group. Patients in the control group were po administered with Levocetirizine hydrochloride tablets before bed, 5 mg/time, once daily. Patients in the treatment group were administered with Fuzhiqing Ointment on affected area on the basis of the control group, twice daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical evaluation was evaluated, the levels of inflammatory factors, perianal pruritus degree, area and shape of lesion, and quality of life index, and recurrence rate in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, tumor necrosis factor-α (TNF- α) and interleukin-6 (IL-6) were significantly decreased, while interferon-γ (IFN- γ) were significantly increased (P < 0.05), and IL-6, TNF-α and IFN-γ in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the area and shape of skin lesions, the degree of perianal pruritus, and the scores of quality of life index were significantly decreased in two groups (P < 0.05), and which were significantly lower in the treatment group (P < 0.05). After treatment, the 3-month recurrence rate and 6-month recurrence rate in the treatment group were significantly lower than those in the control group (P < 0.05).Conclusion Fuzhiqing Ointment combined with levocetirizine in treatment of chronic perianal eczema can effectively improve the clinical symptoms, reduce the recurrence rateand level of inflammatory factors with reliable curative effect.
[中圖分類號(hào)]
R986
[基金項(xiàng)目]
國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目(81330088)