通過查閱文獻和總結(jié)管理實踐，歸納了影響用藥安全的潛在風險因素和管理實踐需關(guān)注的要點，為臨床實踐提供參考。用藥錯誤、藥品不良反應(yīng)、超說明書用藥以及藥品質(zhì)量缺陷是威脅用藥安全的潛在風險因素。醫(yī)療機構(gòu)用藥安全的影響因素眾多，除了與藥物本身相關(guān)外，用藥安全還與患者、醫(yī)務(wù)工作者、工作流程、工作環(huán)境、藥學設(shè)備和管理等因素有關(guān)。結(jié)合管理實踐經(jīng)驗，用藥安全的管理需要全員參與、全面覆蓋，從人員、流程、硬件、軟件和環(huán)境等多方面查漏補缺、持續(xù)改進，才能筑牢醫(yī)療機構(gòu)用藥安全的防線。

The potential risk factors that affecting drug safety were systematically summarized through literature review, and the key points of corresponding management practice were also summarized, to provide reference for clinical practice. Medication errors, adverse drug reactions, off-label drug use, and drug quality defects are potential risk factors of drug safety. There are many factors influencing drug safety in medical institutions, in addition to the drug itself, patients, medical workers, workflow, work environment, pharmaceutical equipment, and the management are all factors that relevant to drug safety, which needs full participation and full process management. With the rich experience in management practice, we should find out the potential problems from personnel, processes, hardware, software and work environment, then make continuous improvement, in order to ensure the safety of patients.

R951

國家自然科學基金青年科學基金項目（82104310）；北京醫(yī)衛(wèi)健康公益基金會醫(yī)學科學研究基金項目（B20199FN）