白芍總苷可以改善動脈粥樣硬化程度和心肌重構、減輕心肌缺血、縮小心肌梗死面積、減輕心肌缺血再灌注損傷，具有心肌和血管保護作用，其機制與調節(jié)血脂、抗血小板聚集、抑制氧化應激、減輕炎癥損傷、抑制細胞凋亡/焦亡相關。通過系統(tǒng)梳理文獻，深入探討白芍總苷的心血管保護效應及其作用機制，為白芍總苷防治心血管疾病提供新策略。

Total glucoside of paeony (TGP) can improve the degree of atherosclerosis and myocardial remodeling, relieve myocardial ischemia, decrease the size of myocardial infarction, reduce myocardial ischemia-reperfusion injury, and has myocardial and vascular protective effects. Its mechanism is related to regulating blood lipid, anti-platelet aggregation, inhibiting oxidative stress, reducing inflammatory injury and inhibiting apoptosis / pyroptosis. Through systematic review of literature reports, this article discusses in depth the cardiovascular protective effects of TGP and its mechanism of action, and provides a new strategy for TGP to prevent and treat cardiovascular diseases.

R972

天津市衛(wèi)生計生行業(yè)高層次人才選拔培養(yǎng)工程；中華中醫(yī)藥學會青年人才托舉工程項目（CACM-2018-QNRC2-B04）