目的 探討仙靈骨葆膠囊聯(lián)合骨肽片治療橈骨遠端骨折的臨床療效。方法 選取2018年10月-2020年12月在商丘市立醫(yī)院就診的106例橈骨遠端骨折患者,按照隨機數(shù)字表法將患者分為對照組和治療組,每組各53例。對照組患者口服骨肽片,1.2 g/次,3次/d。治療組患者在對照組基礎上口服仙靈骨葆膠囊,1.5 g/次,2次/d。15 d為1個療程,兩組連續(xù)治療2個療程。觀察兩組的臨床療效,比較兩組患者的主要癥狀消失時間、疼痛程度和血清因子水平。結果 治療后,治療組的總有效率為92.45%,明顯高于對照組總有效率77.36%(P<0.05)。治療后,治療組的止痛時間、消腫時間、骨折愈合時間明顯短于對照組(P<0.05)。治療后,兩組VAS評分顯著減小(P<0.05);且治療組VAS評分明顯小于對照組(P<0.05)。治療后,兩組的胰島素樣生長因子-1(IGF-1)、轉化生長因子-β₁(TGF-β₁)、血管內(nèi)皮生長因子(VEGF)水平均明顯升高(P<0.05);治療后,治療組的IGF-1、TGF-β₁、VEGF水平比對照組高(P<0.05)。結論 仙靈骨葆膠囊聯(lián)合骨肽片治療橈骨遠端骨折的療效確切,能促使骨折愈合減輕疼痛程度,調(diào)節(jié)IGF-1、TGF-β₁、VEGF的分泌,安全性較好。

Objective To investigate the clinical effect of Xianling Gubao Capsules combined with Ossotide Tablets in treatment of distal radius fractures.Methods Patients (106 cases) with distal radius fractures in Shangqiu Municipal Hospital from October 2018 to December 2020 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Ossotide Tablets, 1.2 g/time, three times daily. Patients in the treatment group were po administered with Xianling Gubao Capsules on the basis of the control group, 1.5 g/time, twice daily. A course of treatment had15 d, and patients in two groups were treated for 2 courses. After treatment, the clinical efficacies were evaluated, and the disappearance time of main symptoms, the degree of pain, and the serum level of factors in two groups were compared.Results After treatment, the total effective rate of the treatment group was 92.45%, which was significantly higher than 77.36% in the control group (P < 0.05). After treatment, the analgesic time, detumescence time, and fracture healing time in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the VAS score of the two groups were significantly decreased (P < 0.05); the VAS score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the levels of IGF-1, TGF-β1, and VEGF in the two groups were significantly increased (P < 0.05). After treatment, the levels of IGF-1, TGF-β1, and VEGF in the treatment group were higher than those in the control group (P < 0.05).Conclusion Xianling Gubao Capsules combined with Ossotide Tablets is effective in treatment of distal radius fractures, can promote fracture healing, reduce pain, and regulate the secretion of IGF-1, TGF and VEGF, with good safety.

R982

河南省醫(yī)學科技攻關計劃(聯(lián)合共建項目)(2018020709)