蘆薈大黃素為蒽醌類化合物，主要來源于蘆薈、大黃、巴天酸模、山扁豆等植物中，具有良好的抗菌、瀉下作用。近年來，研究者在對蘆薈大黃素藥理活性的研究中發(fā)現(xiàn)其有巨大的抗腫瘤潛力。從誘導腫瘤細胞凋亡、抑制腫瘤細胞增殖、抑制腫瘤細胞侵襲和轉移、誘導腫瘤細胞自噬、抗炎、免疫調節(jié)方面對蘆薈大黃素的抗腫瘤作用機制進行綜述，為其進一步的應用、開發(fā)提供參考。

Aloe-emodin is an anthraquinone compound, mainly from Aloe vera (Linn.) N. L. Burman var. chinensis (Haw.) Berg., Rheum officinale Baill., Rumex patientia Linn., Cassia mimosoides L. and other plants, with good antibacterial and laxative effects. In recent years, researchers have found that aloe-emodin has great anti-tumor potential in its study of the pharmacological activity. This article reviews the anti-tumor mechanisms of aloe-emodin, such as inducing tumor cell apoptosis, inhibiting tumor cell proliferation, inhibiting tumor cell invasion and metastasis, inducing tumor cell autophagy, anti-inflammatory, and immune regulation, to provide reference for its further application and development.

R979.1

國家自然科學基金資助項目(81760491);廣西科學技術廳科技開發(fā)項目(桂科攻1355004-8);廣西醫(yī)療衛(wèi)生適宜技術開發(fā)與推廣應用項目(S2020106);2022年度廣西高校中青年教師科研基礎能力提升項目(2022KY0502);桂林市科學研究與技術開發(fā)計劃項目(20210227-8-7)