目的 探討醒腦靜注射液聯(lián)合吡拉西坦注射液治療腦挫裂傷的臨床療效。方法 選取2020年1月—2021年11月天津市寧河區(qū)醫(yī)院收治的94例腦挫裂傷患者，根據(jù)隨機數(shù)字表法將所有患者分為對照組和治療組，每組各47例。對照組靜脈滴注吡拉西坦注射液，40 mL加入250 mL生理鹽水，1次/d。治療組在對照組治療的基礎(chǔ)上靜脈滴注醒腦靜注射液，20 mL加入250 mL葡萄糖注射液充分稀釋，1次/d。兩組患者連續(xù)治療2周。觀察兩組的臨床療效，比較兩組患者的清醒時間、住院時間、神經(jīng)缺損程度和昏迷程度以及血清中白細胞介素-8（IL-8）、血管內(nèi)皮生長因子（VEGF）、神經(jīng)元特異性烯醇化酶（NSE）的水平。結(jié)果 治療后，治療組的總有效率（95.74%）高于對照組（82.98%），組間比較差異顯著（P<0.05）。治療后，治療組的清醒時間、住院時間明顯短于對照組（P<0.05）。治療后，兩組美國國立衛(wèi)生研究院卒中量表（NIHSS）評分低于治療前，格拉斯哥昏迷量表（GCS）評分高于治療前（P<0.05）；治療后，治療組的NIHSS評分低于對照組，GCS評分高于對照組（P<0.05）。治療后，兩組的血清IL-8、VEGF、NSE水平低于治療前（P<0.05），且治療組血清IL-8、VEGF、NSE水平較對照組更低，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 醒腦靜注射液聯(lián)合吡拉西坦注射液治療腦挫裂傷的療效確切，能改善昏迷程度和降低神經(jīng)功能缺損，安全性良好。

Objective To investigate the clinical efficacy of Xingnaojing Injection combined with Piracetam Injection in treatment of brain contusion and laceration. Methods Patients (94 cases) with brain contusion and laceration in Tianjin Ninghe Hospital from January 2020 to November 2021 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were po administered with Piracetam Injection, 40 mL added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Xingnaojing Injection on the basis of the control group, 20 mL added into glucose injection 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the awake time, the hospital stay, the degree of nerve defect, the degree of coma, the serum levels of IL-8, VEGF, and NSE in two group were compared. Results After treatment, the total effective rate of the treatment group (95.74%) was higher than that of the control group (82.98%), and there was significant reference between two groups (P < 0.05). After treatment, the awake time and hospital stay in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the NIHSS score of two groups was lower than that before treatment, but the GCS score of two groups was higher than that before treatment (P < 0.05). After treatment, the NIHSS score of the treatment group was lower than that of the control group, but the GCS score of the treatment group was higher than that of the control group (P < 0.05). After treatment, the serum levels of IL-8, VEGF, and NSE in two groups were lower than those before treatment (P < 0.05), and the serum levels of IL-8, VEGF, and NSE in the treatment group were lower than those in the control group (P< 0.05). Conclusion Xingnaojing Injection combined with Piracetam Injection has curative effect in treatment of brain contusion and laceration, can improve the degree of coma, and reduce neurological deficit, with good safety.

R971

河北省醫(yī)學(xué)科學(xué)研究課題計劃項目（20200293）