目的 觀察清咳平喘顆粒聯(lián)合沙美特羅替卡松吸入粉霧劑治療熱傷肺絡(luò)型咳嗽變異性哮喘的臨床療效。方法 選取2020年3月—2021年3月在哈爾濱市中醫(yī)醫(yī)院呼吸科門診就診的100例熱傷肺絡(luò)型咳嗽變異性哮喘患者，采用隨機(jī)數(shù)字表法將所有患者分為對照組和治療組，每組各50例。對照組患者給予沙美特羅替卡松吸入粉霧劑，1吸（泡）/次，2次/d。治療組在對照組的基礎(chǔ)上開水沖服清咳平喘顆粒，10 g/次，3次/d。兩組患者均連續(xù)治療4周。觀察兩組患者臨床療效，比較兩組患者的中醫(yī)證候積分、肺功能指標(biāo)和血清免疫功能指標(biāo)水平。結(jié)果 治療后，治療組患者的總有效率為90.00%，明顯高于對照組的總有效率80.00%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者咳嗽、咳痰、喘息、哮鳴音評分均顯著降低（P<0.05），且治療后治療組患者咳嗽、咳痰、喘息、哮鳴音評分明顯低于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者第1秒用力呼氣容積（FEV_l）、最大呼氣流速（PEF）、FEV₁/FVC均顯著升高（P<0.05），且治療組FEV_l、PEF、FEV₁/FVC顯著高于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清嗜酸性粒細(xì)胞（EOS）、免疫球蛋白E（IgE）水平均顯著降低（P<0.05），且治療組的血清EOS、IgE水平均低于對照組，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 清咳平喘顆粒聯(lián)合沙美特羅替卡松吸入粉霧劑治療熱傷肺絡(luò)型咳嗽變異性哮喘具有較好的臨床療效，可緩解患者臨床癥狀，改善肺功能指標(biāo)，有效恢復(fù)患者EOS、IgE至正常水平，具有良好的臨床安全性。

Objective To observe the clinical efficacy of Qingke Pingchuan Granules combined with Salmeterol Xinafoate and Fluticasone Propionate Powder for inhalation in treatment of cough variant asthma of heat-injured lung complex type. Methods Patients (100 cases) with cough variant asthma of heat-injured lung complex type in Harbin Traditional Chinese Medicine Hospital from March 2020 to March 2021 were divided into control and treatment groups according to random number table, and each group had 50 cases. Patients in the control group were given Salmeterol Xinafoate and Fluticasone Propionate Powder for inhalation, 1 suction (bubble)/time, twice daily. Patients in the treatment group were po administered with Qingke Pingchuan Granules on the basis of the control group, 10 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the scores of traditional Chinese medicine syndromes, the lung function indexes, the serum levels of immune function indexes in two groups were compared. Results After treatment, the total effective rate of the treatment group was 90.00%, which was significantly higher than 80.00% of the control group (P < 0.05). After treatment, the scores of cough, expectoration, wheezing, and wheezing in two groups were significantly decreased (P < 0.05), and the scores of cough, expectoration, wheezing, and wheezing in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, FEV_l, PEF, and FEV₁/FVC of the two groups were significantly increased (P < 0.05), and FEV_l, PEF, and FEV₁/FVC in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the levels of EOS and IGE in two groups were significantly decreased (P < 0.05), and the levels of EOS and IgE in the treatment group were lower than those in the control group (P < 0.05). Conclusion Qingke Pingchuan Granules combined with Salmeterol Xinafoate and Fluticasone Propionate Powder for inhalation in treatment of cough variant asthma of heat-injured lung complex type can alleviate patients' clinical symptoms, improve pulmonary function indexes, effectively restore patients' EOS and IgE to normal levels, with good clinical safety.

R974