[關鍵詞]
[摘要]
尿激酶型纖溶酶原激活物受體(uPAR)是一種糖基磷脂酰肌醇錨定的膜蛋白,已被發(fā)現(xiàn)在多種癌細胞中過表達,這一特性使得uPAR成為治療癌癥的一個理想靶標。目前,多種以uPAR為靶點的抗癌藥物已被開發(fā),主要包括多肽、單克隆抗體、配體靶向毒素。此外,uPAR作為靶點也已在納米藥物遞送系統(tǒng)和光熱療法(PTT)/光動力療法(PDT)中得到應用。因此就靶向uPAR的抗腫瘤藥物的研究進展做一綜述。
[Key word]
[Abstract]
Urokinase-type plasminogen activator receptor (uPAR) is a glycosyl phosphatidyl inositol-anchored membrane protein which has been found to be over-expressed in a variety of cancer cells, and this property makes uPAR a promising candidate for cancer treatment. At present, a variety of anti-tumor drugs targeting uPAR have been developed, mainly including peptides, monoclonal antibodies, and ligand-targeted toxins. In addition, uPAR has also been used as a target in nano-drug delivery systems and photothermal therapy (PTT)/photodynamic therapy (PDT). Therefore, this paper reviews the research progress of anti-tumor drugs targeting uPAR.
[中圖分類號]
R979.1
[基金項目]
陜西省教育廳重點科研計劃項目(21JS009);陜西省科技廳自然科學基礎研究計劃項目(2022JQ-932);西安市衛(wèi)生健康委員會項目(SZY202103)