[關(guān)鍵詞]
[摘要]
目的 探討棗仁安神顆粒聯(lián)合右佐匹克隆片治療老年原發(fā)性失眠的臨床療效。方法 選取2020年4月—2021年4月在武漢市第一醫(yī)院神經(jīng)內(nèi)科睡眠與心理門診就診的96例老年原發(fā)性失眠癥患者,根據(jù)隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組,每組48例。對(duì)照組睡前口服右佐匹克隆片,2 mg/次,1次/d。治療組在對(duì)照組基礎(chǔ)上睡前口服棗仁安神顆粒,1袋/次,1次/d。兩組患者連續(xù)治療4周。觀察兩組的臨床療效,比較兩組的睡眠質(zhì)量、睡眠指標(biāo)以及血清中腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)、神經(jīng)肽Y(NPY)、腫瘤壞死因子-α(TNF-α)水平。結(jié)果 治療后,治療組患者的總有效率為89.58%,對(duì)照組的總有效率為72.92%,兩組比較有明顯差異(P<0.05)。治療后,兩組的匹茲堡睡眠質(zhì)量指數(shù)(PSQI)量表評(píng)分均低于治療前(P<0.05);治療后,治療組的PSQI評(píng)分低于對(duì)照組(P<0.05)。治療后,兩組的慢波睡眠(SWS)、睡眠效率(SE)高于治療前,覺(jué)醒時(shí)間(AT)低于治療前(P<0.05);治療后,治療組患者的SWS、SE高于對(duì)照組,AT低于對(duì)照組(P<0.05)。治療后,兩組的血清BDNF、NPY水平高于治療前,血清TNF-α水平低于治療前(P<0.05);治療后治療組的BDNF、NPY水平高于對(duì)照組,TNF-α低于對(duì)照組(P<0.05)。結(jié)論 棗仁安神顆粒聯(lián)合右佐匹克隆片治療老年失眠癥療效確切,能改善睡眠質(zhì)量,調(diào)節(jié)SWS、SE、AT,升高BDNF、NPY水平,降低TNF-α水平,安全性較好。
[Key word]
[Abstract]
ObjectiveTo investigate the curative effect of Zaoren Anshen Granules combined with Dexzopiclone Tablets in treatment of senile primary insomnia Methods Patients (96 cases) with senile primary insomnia in Wuhan First Hospital from April 2020 to April 2021 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Dexzopiclone Tablets, 2 mg/time, once daily. Patients in the treatment group were po administered with Zaoren Anshen Granules on the basis of the control group, 1 bag/time, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the sleep quality, sleep index, and the levels of BDNF, NPY, and TNF-α in two groups were compared. Results After treatment, the total effective rate was 89.58% in the treatment group and 72.92% in the control group, and there was significant difference between two groups (P < 0.05). After treatment, the PSQI scores of two groups were lower than those before treatment (P < 0.05). After treatment, the PSQI score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the SWS and SE of two groups were higher than before treatment, but AT of two groups was lower than before treatment (P < 0.05). After treatment, the SWS and SE in the treatment group were higher than those in the control group, but AT in the treatment group was lower than those in the control group (P < 0.05). After treatment, the serum levels of BDNF and NPY in two groups were higher than those before treatment, but the serum level of TNF-α in two groups was lower than that before treatment (P < 0.05); After treatment, the BDNF and NPY in the treatment group were higher than those in the control group, but the serum level of TNF-α in the treatment group was lower than those in the control group (P < 0.05). Conclusion Zaoren Anshen Granules combined with Dexzopiclone Tablets is effective in treatment of senility primary insomnia, which can improve sleep quality, regulate SWS, SE, and AT, increase the levels of BDNF and NPY, and reduce the level of TNF-α, with good safety.
[中圖分類號(hào)]
R971
[基金項(xiàng)目]
武漢市醫(yī)學(xué)科研項(xiàng)目(WX20B23)