目的 探討丙卡特羅聯(lián)合地塞米松磷酸鈉治療兒童支氣管哮喘急性發(fā)作的臨床研究。方法 選擇2021年1月—2022年1月在南通市海門區(qū)人民醫(yī)院診療的80例支氣管哮喘急性發(fā)作患兒，隨機(jī)分對照組（40例）和治療組（40例）。對照組患兒靜脈滴注地塞米松磷酸鈉注射液，每次0.5 mg/kg，1次/d。治療組在對照組的基礎(chǔ)上口服鹽酸丙卡特羅口服溶液，5 mL/次，2次/d。兩組患兒連續(xù)治療5 d。觀察兩組患兒臨床療效，比較治療前后兩組患兒癥狀好轉(zhuǎn)時間，及血清白細(xì)胞介素-1β（IL-1β）、白細(xì)胞介素-17（IL-17）、腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）水平。結(jié)果 治療后，治療組臨床有效率為97.50%，明顯高于對照組77.50%（P<0.05）。治療后，治療組癥狀好轉(zhuǎn)時間均明顯早于對照組（P<0.05）。治療后，兩組患兒IL-1β、IL-17、TNF-α、CRP水平均明顯降低，且治療組明顯均低于對照組（P<0.05）。結(jié)論 地塞米松磷酸鈉聯(lián)合鹽酸丙卡特羅治療支氣管哮喘急性發(fā)作患兒效果明顯，可有效改善支氣管炎癥反應(yīng)，促進(jìn)機(jī)體免疫力增加。

Objective To explore the clinical study of procaterol hydrochloride combined with dexamethasone sodium phosphate in treatment of acute exacerbation of bronchial asthma in children. Methods Children (80 cases) with acute exacerbation of bronchial asthma in Nantong Haimen People's Hospital from January 2021 to January 2022 were randomly divided into control (40 cases) and treatment (40 cases) group. Children in the control group were iv administered with Dexamethasone Sodium Phosphate Injection, 0.5 mg/kg at a time, once daily. Children in the treatment group were po administered with Procaterol Hydrochloride Oral Solution on the basis of the control group, 5 mL/time, twice daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, the improvement time of symptoms, the levels of serological indexes IL-1β, IL-17, TNF-α, and CRP in two groups before and after treatment were compared. Results After treatment, the effective rate in the treatment group was higher than that in the control group (97.50% vs 77.50%, P < 0.05). After treatment, the improvement time of symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of IL-1β, IL-17, TNF-α, CRP were significantly lower in the treatment group than which in the control group (P < 0.05). Conclusion The effect of Dexamethasone sodium phosphate combined with procaterol hydrochloride in treatment of acute exacerbation of bronchial asthma in children is obvious, which can effectively improve the reaction of bronchitis and promote the increase of body immunity.

R974