目的 探討鼻康片聯(lián)合色甘萘甲那敏治療過敏性鼻炎的臨床療效。方法 回顧性分析2020年10月—2021年10月在武漢市紅十字醫(yī)院治療的110例過敏性鼻炎患者的臨床資料，隨機(jī)分為對照組和治療組，每組各55例。對照組給予色甘萘甲那敏鼻噴霧劑，每次兩側(cè)鼻孔各噴1下，3～5次/d，每次間隔>3 h；在對照組基礎(chǔ)上，治療組口服鼻康片，5片/次，3次/d。兩組患者均連續(xù)治療8周。觀察兩組患者臨床療效，比較治療前后兩組患者過敏性鼻炎生活質(zhì)量測評量表（RQLQ）、鼻癥狀總分表（TNSS）、伴隨癥狀總分（TNNSS）和鼻內(nèi)鏡（MLK）評分，血清白細(xì)胞介素-13（IL-13）、白細(xì)胞介素-23（IL-23）、白細(xì)胞介素-27（IL-27）、可溶性血管細(xì)胞間黏附分子-1（sICAM-1）、可溶性程序性死亡配體-1（sPD-L1）和可溶性E-選擇素（sE-selectin）水平，鼻通氣功能指標(biāo)總鼻氣道阻力（NAR）、0～5 cm鼻腔容積（NCV）和鼻腔最小橫截面積（NMCA）水平。結(jié)果 治療后，對照組有效率為81.82%，明顯低于治療組96.36%（P<0.05）。治療后，兩組RQLQ、TNSS、TNNSS和MLK評分均明顯改善（P<0.05）；兩組患者血清IL-13、IL-23、sICAM-1和sE-selectin水平均明顯降低，而sPD-L1和IL-27水平明顯升高（P<0.05）；兩組0～5 cm NCV、NMCA均明顯升高，而NAR均明顯降低（P<0.05）；且治療組這些指標(biāo)較對照組改善更明顯（P<0.05）。結(jié)論 鼻康片聯(lián)合色甘萘甲那敏鼻噴霧劑治療過敏性鼻炎可有效改善患者鼻部癥狀，提高鼻通氣，改善血清細(xì)胞因子表達(dá)，有利于提高患者生活質(zhì)量。

Objective To explore the clinical efficacy of Bikang Tablets combined with sodium cromoglicate, naphazoline hydrochloride and chlorphenamine maleate in treatment of allergic sinusitis. Methods The clinical data of 110 patients with allergic rhinitis treated in Wuhan Red Cross Hospital from October 2020 to October 2021 were analyzed retrospectively, they were randomly divided into control and treatment group, and each had 55 cases. Patients in the control group were administered with Sodium Cromoglicate, Naphazoline hydrochloride and Chlorphenamine Maleate Nasal Spray, one nostril spray at a time, 3 to 5 times daily with an interval of more than 3 h. Patients in the treatment group were po administered with Bikang Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, the scores of RQLQ, TNSS, TNNSS and MLK, the levels of serum IL-13, IL-23, sICAM-1, sE-selectin, sPD-L1 and IL-27, and the nasal respiration function indexes of 0-5 cm NCV, NMCA and NAR in two groups before and after treatment were compared. Results After treatment, the effective rate in the control group was 81.82%, which was significantly lower than 96.36% in the treatment group (P < 0.05). After treatment, the scores of RQLQ, TNSS, TNNSS and MLK were significantly improved in two groups (P < 0.05), the levels of serum IL-13, IL-23, sICAM-1 and sE-selectin were significantly decreased (P < 0.05), the levels of sPD-L1 and IL-27 were significantly increased (P < 0.05), 0-5 cm NCV, NMCA and NAR were significantly increased (P < 0.05), and these indexes were most significantly improved in the treatment group (P < 0.05). Conclusion Bikang Tablets combined with Sodium Cromoglicate, Naphazoline hydrochloride and Chlorphenamine Maleate Nasal Spray in the treatment of allergic sinusitis can effectively improve the nasal symptoms of patients, the nasal ventilation, improve the expression of serum cytokines, and it is beneficial to improve the quality of life of patients.

R976

武漢市醫(yī)學(xué)科研項(xiàng)目（WX21B26）