目的 探討婦科養(yǎng)血顆粒聯(lián)合屈螺酮炔雌醇治療功能性子宮出血的臨床療效。方法 選擇2020年1月—2022年1月在聊城市第二人民醫(yī)院診療的200例子宮出血者，隨機分對照組（100例）和治療組（100例）。對照組患者口服屈螺酮炔雌醇片，1片/次，1次/d。治療組在對照組的基礎(chǔ)上口服婦科養(yǎng)血顆粒，1袋/次，2次/d。兩組治療7周。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀改善時間，性激素垂體分泌卵泡雌激素（FSH）、雌二醇（E₂）、促黃體生成素（LH）和睪酮激素（T）水平，血清白細(xì)胞介素-2（IL-2）、血管內(nèi)皮生長因子A（VEGFA）、腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）水平，及不良反應(yīng)情況。結(jié)果 治療后，治療組臨床有效率明顯高于對照組（98.00%vs 89.00%，P<0.05）。治療后，治療組癥狀改善時間均明顯早于對照組（P<0.05）。治療后，兩組FSH水平明顯升高，而E₂、LH、T、IL-2、VEGFA、TNF-α、CRP水平明顯降低（P<0.05），且治療組性激素水平和血清炎性因子水平明顯好于對照組（P<0.05）。治療組不良發(fā)生率（7.00%）明顯低于對照組（13.00%，P<0.05）。結(jié)論 婦科養(yǎng)血顆粒聯(lián)合屈螺酮炔雌醇治療功能性子宮出血，可明顯縮短止血時間，明顯改善性激素水平，降低炎性因子，且安全有效。

Objective To investigate the efficacy of Fuke Yangxue Granules combined with drospirenone and ethinylestradiol in treatment of functional uterine bleeding. Methods Patients (200 cases) with functional uterine bleeding in the Second People's Hospital of Liaocheng from January 2020 to January 2022 were randomly divided into control (100 cases) and treatment (100 cases) group. Patients in the control group were po administered with Drospirenone and Ethinylestradiol Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Fuke Yangxue Granules on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 7 weeks. After treatment, the clinical evaluation was evaluated, the improvement time of symptoms, the levels of hormone FSH, E₂, LH and T, the levels of serum IL-2, VEGFA, TNF-α and CRP, and the adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (98.00% vs 89.00%, P < 0.05). After treatment, the improvement time of symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the level of FSH was significantly increased in two groups, while the level of E₂, LH, T, IL-2, VEGFA, TNF-α and CRP was significantly decreased (P < 0.05), and the level of sex hormones and serum inflammatory factors in the treatment group were significantly better than those in the control group (P < 0.05). the incidence of adverse reactions in the treatment group (7.00%) was significantly lower than that in the control group (13.00%, P < 0.05). Conclusion Fuke Yangxue Granules combined with drospirenone and ethinylestradiol in treatment of functional uterine bleeding can significantly shorten the hemostatic time, significantly improve the level of sex hormones and reduce inflammatory factors, and is safe and effective.

R984