[關(guān)鍵詞]
[摘要]
腫瘤微環(huán)境在腫瘤的發(fā)生、發(fā)展、轉(zhuǎn)移等環(huán)節(jié)起到至關(guān)重要的作用。多種中藥多糖通過調(diào)控腫瘤微環(huán)境而展現(xiàn)出抗腫瘤作用。從腫瘤微環(huán)境的各個(gè)組成部分如腫瘤相關(guān)成纖維細(xì)胞、腫瘤免疫細(xì)胞、血管內(nèi)皮細(xì)胞、細(xì)胞外基質(zhì)出發(fā)，闡述黃芪多糖、豬苓多糖、香菇多糖、車前子多糖、人參多糖、羊棲菜多糖和枸杞多糖對(duì)腫瘤微環(huán)境的調(diào)控作用，為抗腫瘤中藥多糖藥物的研發(fā)提供參考。
[Key word]
[Abstract]
The tumor microenvironment plays an important role in the occurrence, development, and metastasis of tumors. A variety of traditional Chinese medicine polysaccharides have anti-tumor effects by regulating the tumor microenvironment. Starting from various components of the tumor microenvironment, such as tumor-associated fibroblasts, tumor immune cells, vascular endothelial cells, and extracellular matrix, this paper describes the regulatory effects of astragalus polysaccharides, polyporus polysaccharides, lentinan, Semen plantaginis polysaccharides, ginseng polysaccharides, Sargassum fusiforme polysaccharides, and Lycium barbarum polysaccharides on the tumor microenvironment, which can provide reference for the research and development of anti-tumor traditional Chinese medicine polysaccharide drugs.
[中圖分類號(hào)]
R966
[基金項(xiàng)目]
國(guó)家自然科學(xué)基金資助項(xiàng)目（81703685）；中國(guó)博士后科學(xué)基金項(xiàng)目（2017M621319）；黑龍江省自然科學(xué)基金項(xiàng)目（LH2019H056）；黑龍江省中醫(yī)藥科研項(xiàng)目（ZHY18-021）
