慢性腎臟病一直以來是世界范圍內(nèi)的公共衛(wèi)生問題，一旦錯過早期干預期，進入終末期腎臟病只能行腎臟替代治療來維持生存。槲皮素是一種植物類黃酮，槲皮素及其衍生物具有抗氧化、抗炎、抗菌、抗凋亡、抗纖維化等作用。槲皮素及其衍生物槲皮素3-O-葡萄糖苷酸、二氫槲皮素能夠抑制氧化應激、抑制炎癥反應、抑制纖維化、抑制細胞凋亡、調(diào)節(jié)腸道菌群、預防造影劑腎病，在保護腎臟方面發(fā)揮重要作用。對槲皮素及其衍生物治療慢性腎臟病的作用機制進行綜述，希望為臨床用藥提供參考。

Chronic kidney disease has always been a worldwide public health problem. If chronic kidney disease misses the early intervention period and enters end-stage renal disease, only renal replacement therapy can be used to maintain survival. Quercetin is a kind of natural flavonoid, and quercetin and its derivatives have antioxidant, anti-inflammatory, antibacterial, anti-apoptotic, and anti-fibrotic effects. Quercetin and its derivatives quercetin 3-O-glucuronide and dihydroquercetin can inhibit oxidative stress, inhibit inflammatory response, inhibit fibrosis, inhibit apoptosis, regulate intestinal flora, and prevent contrast Nephropathy, and it also plays an important role in protecting the kidneys. This article reviews the mechanism of quercetin and its derivatives in treatment of chronic kidney disease, hoping to provide a reference for clinical practice.

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