骨關(guān)節(jié)炎是一種慢性退行性關(guān)節(jié)疾病，也是導(dǎo)致老年人慢性功能障礙的主要因素。二甲雙胍是目前公認(rèn)用于治療糖尿病的一線藥物，可能也對(duì)骨關(guān)節(jié)炎軟骨具有保護(hù)作用。二甲雙胍抑制軟骨細(xì)胞炎癥反應(yīng)、調(diào)節(jié)軟骨細(xì)胞代謝異常、影響軟骨細(xì)胞分化。對(duì)二甲雙胍治療骨關(guān)節(jié)炎的作用機(jī)制做一綜述，為二甲雙胍臨床應(yīng)用提供參考。

Osteoarthritis is a chronic degenerative joint disease and a major factor to chronic dysfunction in the elderly. Metformin, currently recognized as the first-line drug for treatment of diabetes, may also have protective effects on cartilage in osteoarthritis. Metformin inhibits chondrocyte inflammatory response, regulates abnormal chondrocyte metabolism, and affects chondrocyte differentiation. This article reviews the mechanism of metformin in treatment of osteoarthritis, and provides a reference for the clinical application of metformin.

R966

遼寧省教育廳科學(xué)研究經(jīng)費(fèi)項(xiàng)目（L202060）