聚賴(lài)氨酸是一種天然的陽(yáng)離子聚酰胺聚合物，具有良好的生物相容性和生物可降解性，因而在生物醫(yī)學(xué)應(yīng)用中顯示出巨大的潛力。聚賴(lài)氨酸側(cè)鏈上眾多的氨基基團(tuán)為功能化提供了結(jié)合位點(diǎn)，可形成眾多衍生物。聚賴(lài)氨酸的高分子材料具有陽(yáng)離子特性、生物相容性、無(wú)毒性和刺激響應(yīng)特性，在生物醫(yī)學(xué)領(lǐng)域中得到實(shí)際應(yīng)用。介紹了聚賴(lài)氨酸在遞送系統(tǒng)、生物黏合劑和生物纖維等生物醫(yī)學(xué)領(lǐng)域的應(yīng)用，希望挖掘聚賴(lài)氨酸類(lèi)材料在生物醫(yī)學(xué)應(yīng)用方面巨大的潛力。

Polylysine is a natural cationic polyamide polymer with good biocompatibility and biodegradability,which shows great potential in biomedical applications.A large number of amino groups in the polylysine side chain provide binding sites for functionalization and can form many derivatives.Poly-lysine-based polymer materials have water solubility,biocompatibility,non-toxicity,and stimulus response,and it has been widely used in the field of biomedicine.This paper introduces the application of polylysine in biomedical fields such as delivery systems,biological adhesives and biological fibers,hoping to tap the huge potential of polylysine materials in biomedical applications.

國(guó)家重點(diǎn)研發(fā)計(jì)劃中醫(yī)藥現(xiàn)代化研究重點(diǎn)專(zhuān)項(xiàng)(2018YFC1706700)