目的 觀察清熱散結(jié)膠囊聯(lián)合吸入用布地奈德混懸液治療急性咽炎的臨床療效。方法 選取2021年6月—2022年3月在天津市第五中心醫(yī)院診治的90例急性咽炎患者，將入選的患者根據(jù)隨機數(shù)字表法分為對照組和治療組，每組各45例。對照組患者霧化吸入吸入用布地奈德混懸液，2mg/次，1次/d。治療組在對照組治療的基礎(chǔ)上口服清熱散結(jié)膠囊，3粒/次，3次/d。兩組患者均連續(xù)治療5d。觀察兩組的臨床療效，比較兩組臨床癥狀緩解情況、血清炎癥因子白細胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，治療組的總有效率為91.11%，對照組患者的總有效率為71.11%，組間比較差異顯著（P<0.05）。治療后，治療組患者的咽痛/咽干癥狀、聲音嘶啞、咳嗽消失時間均明顯短于對照組（P<0.05）。治療后，兩組血清IL-6、TNF-α水平明顯下降（P<0.05），且治療組血清IL-6、TNF-α水平低于對照組（P<0.05）。結(jié)論 清熱散結(jié)膠囊聯(lián)合吸入用布地奈德混懸液治療急性咽炎具有較好的療效，可迅速緩解癥狀，降低炎癥因子水平，安全有效。

Objective To observe the clinical efficacy of Qingre Sanjie Capsules combined with Budesonide Suspension for inhalation in treatment of acute pharyngitis. Methods Patients (90 cases) with acute pharyngitis in Tianjin Fifth Central Hospital from June 2021 to March 2022 were divided into control and treatment groups according to random number table method, and each group had 45 cases. Patients in the control group were inhale administered with Budesonide Suspension for inhalation, 2 mg/time, once daily. Patients in the treatment group were po administered with Qingre Sanjie Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and the clinical symptom relief and inflammatory factors (IL-6 and TNF-α) in two groups were compared. Results After treatment, the total effective rate of the treatment group was 91.11%, and the total effective rate of the control group was 71.11%, and there was a significant difference between two groups (P< 0.05). After treatment, disappearance times of sore throat/dry throat symptoms, hoarseness, and cough in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the serum levels of IL-6 and TNF-α in two groups were significantly decreased (P< 0.05), and the serum levels of IL-6 and TNF-α in the treatment group were lower than those in the control group (P < 0.05).Conclusion Qingre Sanjie Capsules combined with Budesonide Suspension for inhalation is effective in the treatment of acute pharyngitis, which can quickly relieve symptoms and reduce the level of inflammatory factors, with good safety.

R987

天津市濱海新區(qū)衛(wèi)計委科技項目（2018BWKY0236）