目的 探討補(bǔ)腎固齒丸聯(lián)合聚維酮碘治療慢性牙周炎的臨床療效。方法 2019年10月—2021年10月在中國人民武裝警察部隊(duì)特色醫(yī)學(xué)中心診治的106例患者，隨機(jī)分對(duì)照組和治療組，每組各53例。對(duì)照組患者含漱聚維酮碘含漱液，10mL/次，含漱10 s后棄去，4次/d。在對(duì)照組的基礎(chǔ)上，治療組口服補(bǔ)腎固齒丸，4g/次，2次/d。兩組用藥14 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀好轉(zhuǎn)時(shí)間，牙周菌斑指數(shù)評(píng)分（PLI）、出血指數(shù)評(píng)分（BI）、牙齦指數(shù)評(píng)分（GI）評(píng)分，血清因子白細(xì)胞介素-1β（IL-1β）、白細(xì)胞介素-6（IL-6）、C反應(yīng)蛋白（CRP）和腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，治療組的臨床有效率（98.11%）明顯高于對(duì)照組（81.13%，P<0.05）。治療后，治療組患者牙齦水腫、牙齒松動(dòng)、咀嚼疼痛、口腔異味等癥狀好轉(zhuǎn)時(shí)間均早于對(duì)照組（P<0.05）。治療后，兩組患者牙周PLI、BI、GI評(píng)分明顯降低（P<0.05），且治療后治療組評(píng)分明顯均低于對(duì)照組（P<0.05）。治療后，兩組血清因子IL-6、IL-1β、TNF-α、CRP水平均明顯下降（P<0.05），且治療組水平均低于對(duì)照組（P<0.05）。結(jié)論 補(bǔ)腎固齒丸聯(lián)合聚維酮碘治療慢性牙周炎，可有效改善患者癥狀及牙周狀態(tài)，并能促進(jìn)機(jī)體炎癥反應(yīng)降低，且安全有效。

Objective To explore the clinical study of Bushen Guchi Pills combined with povidone-iodine in treatment of chronic periodontitis. Methods Patients (106 cases) with chronic periodontitis in Characteristic Medical Center of the Chinese People's Armed Police Force from October 2019 to October 2021 were randomly divided into control and treatment group, and each group had 53 cases. Patients in the control group gargled with Povidone-iodine Gargle and Mouthwash, 10 mL/time for 10 second, four times daily. Patients in the treatment group were po administered with Bushen Guzhi Pills on the basis of the control group, 4 g/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, periodontal PLI, BI and GI score, serum factors IL-6, IL-1β, TNF-α and CRP levels in two groups before and after treatment were compared. Results After treatment, the clinical therapeutic efficiency of the treatment group (98.11%) was significantly higher than that of the control group (81.13%, P < 0.05). After treatment, the improvement time of gingival edema, loose teeth, masticatory pain and bad breath in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the periodontal PLI, BI and GI scores in two groups were significantly decreased (P < 0.05), and the scores of the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the serum levels of IL-6, IL-1β, TNF-α and CRP in two groups were significantly decreased (P< 0.05), and the levels in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of povidone iodine and Bushen Guye Pills can effectively improve the symptoms and periodontal state of the patients, promote the reduction of inflammatory reaction, and which is safe and effective.

R988.2

天津市科技計(jì)劃項(xiàng)目（17JCTPJC0465）