腎功能衰竭是各種慢性腎臟病的終末階段，可發(fā)生腎組織進(jìn)行性不可逆性損傷。丹酚酸B是丹參中主要水溶性化合物，能夠抗腎間質(zhì)纖維化、抗脂質(zhì)氧化反應(yīng)、抗炎癥反應(yīng)、改善腎臟血液循環(huán)、抗細(xì)胞凋亡、抗缺血再灌注損傷、保護(hù)血管內(nèi)皮細(xì)胞功能。綜述了丹酚酸B防治腎功能衰竭的作用機(jī)制，以期為丹酚酸B的臨床使用價(jià)值提供參考。

Renal failure is the end stage of various chronic kidney diseases, which can cause progressive and irreversible damage to renal tissue. Salvianolic acid B is the main water-soluble compound in Salviae Miltiorrhizae Radix et Rhizoma, which can resist renal interstitial fibrosis, resist lipid oxidation reaction, anti-inflammatory response, improve renal blood circulation, resist apoptosis, resist ischemia-reperfusion injury, and protect vascular endothelial cell function. This paper reviews the mechanism of salvianolic acid B in preventing and treating renal failure, in order to provide reference for the clinical use value of salvianolic acid B.

R965

重慶市科衛(wèi)聯(lián)合醫(yī)學(xué)科研項(xiàng)目（2018ZDXM028）