精神分裂癥是一種嚴重精神疾病，患者需要長期甚至終身服用抗精神病藥物。長期使用非典型抗精神病藥物會引起患者葡萄糖耐量降低、血糖升高和血脂異常，使心血管疾病和2型糖尿病的發(fā)病風險增加。關(guān)注非典型抗精神病藥物誘導的糖脂代謝異常，闡明其發(fā)病機制，有助于早期疾病檢測和藥物個體化選擇，對預防藥物不良反應的發(fā)生和提高臨床療效至關(guān)重要。綜述了精神分裂癥患者使用非典型抗精神病藥物引起的糖脂代謝異常及其機制的研究進展，并提出藥物干預對策，為非典型抗精神病藥物的安全應用提供參考。

Schizophrenia is a serious mental disease, and patients need to take antipsychotics for a long time or even for life. Long term use of atypical antipsychotics will lead to decreased glucose tolerance, increased blood sugar and abnormal blood lipids in patients with schizophrenia, and increase the risk of cardiovascular disease and type 2 diabetes. Paying attention to the abnormal glucose and lipid metabolism induced by atypical antipsychotics and clarifying its pathogenesis are helpful for early disease detection and individualized drug selection, and is very important to prevent the occurrence of adverse drug reactions and improve clinical efficacy. This article reviewed the research progress on abnormal glucose and lipid metabolism caused by atypical antipsychotics used in schizophrenia patients and its mechanism, and proposed drug intervention strategies to provide reference for the safe application of atypical antipsychotics.

R964;R977

山東省第一批藥品臨床綜合評價項目（2021YZ026）；濰坊市藥品臨床綜合評價項目（2022WFYP02）