膿毒癥相關(guān)性急性腎損傷目前被認為是與膿毒癥相關(guān)的最嚴重并發(fā)癥之一，病理生理機制仍不明確。右美托咪定是一種新型高效的α₂腎上腺素受體激動劑。在膿毒癥中，右美托咪定可通過抗炎、抗氧化應激、增強自噬調(diào)節(jié)、影響血流動力學來保護腎臟功能，因此就右美托咪定對膿毒癥腎臟功能的保護作用的研究進展進行了綜述。

Sepsis-associated acute kidney injury is currently considered as one of the most serious complications associated with sepsis, and its pathophysiological mechanism is still unclear. Dexmedetomidine is a novel and efficient α₂-adrenergic receptor agonist. In sepsis, dexmedetomidine may protect kidney function by anti-inflammatory, anti-oxidative stress, enhancing autophagy regulation, and affecting hemodynamics. This article reviews the research progress on protection of dexmedetomidine on renal function in sepsis.

R971