炎癥性腸病是一種以慢性、復(fù)雜性、免疫介導(dǎo)為特點(diǎn)的炎癥性疾病,結(jié)腸黏膜免疫系統(tǒng)在其發(fā)生發(fā)展過程中起到了重要作用。黃芩苷是從傳統(tǒng)中藥黃芩中提取分離出的一種黃酮衍生物,具有顯著的藥理活性,包括抗炎、調(diào)節(jié)免疫、抗氧化等。黃芩苷通過影響免疫細(xì)胞調(diào)節(jié)腸道炎癥反應(yīng)、調(diào)節(jié)免疫活性因子影響腸道免疫、調(diào)控信號通路調(diào)節(jié)腸道免疫、多靶點(diǎn)多角度影響腸道屏障等多種環(huán)節(jié)、多條通路、多個(gè)靶點(diǎn)共同作用來實(shí)現(xiàn)治療炎癥性腸病。綜述了黃芩苷治療炎癥性腸病的作用機(jī)制,以期為進(jìn)一步開展相關(guān)研究提供參考。

Inflammatory bowel disease is a chronic, complex, and immune mediated inflammatory disease, and the immune system of colon mucosa plays an important role in occurrence and development of inflammatory bowel disease. Baicalin is a flavonoid derivative extracted from Scutellariae Radix. It has significant pharmacological activities, including anti-inflammatory, immune regulation, and antioxidant, etc. Baicalin can treat inflammatory bowel disease through multiple links, multiple pathways and multiple targets, including affecting immune cells to regulate intestinal inflammatory response, regulating immune active factors to affect intestinal immunity, regulating signal pathways to regulate intestinal immunity, and affecting intestinal barrier through multiple targets and multiple angles. This article reviews the mechanism of baicalin in treatment of inflammatory bowel disease, hoping to provide reference for further research.

R965

江蘇省科技計(jì)劃專項(xiàng)資金(基礎(chǔ)研究計(jì)劃自然科學(xué)基金)項(xiàng)目(BK20221178);江蘇省中醫(yī)藥科技發(fā)展計(jì)劃項(xiàng)目(YB2020029);宿遷市基礎(chǔ)研究計(jì)劃-自然科學(xué)基金項(xiàng)目(K202144)