近些年,侵襲性真菌感染的發(fā)病率逐年增加。由于臨床上單藥治療侵襲性真菌感染的效果欠佳,特別是耐藥真菌的感染,可選擇的藥物極少,導(dǎo)致相關(guān)疾病的發(fā)病率和死亡率仍很高,故抗真菌藥物的聯(lián)合治療得到了廣大學(xué)者的青睞?？偨Y(jié)了抗真菌藥物聯(lián)合治療侵襲性真菌感染的機(jī)制,綜述了針對中樞神經(jīng)系統(tǒng)、肺部、血液系統(tǒng)、其他部位侵襲性真菌感染的聯(lián)合用藥情況,為臨床合理使用抗菌藥物提供參考依據(jù)。

In recent years, the incidence of invasive fungal infection has been increasing year by year. Due to the poor clinical efficacy of single drug in treatment for invasive fungal infections, especially for drug-resistant fungal infections, and few drugs to choose, it had led to a high incidence rate and mortality rate of related diseases. Therefore, combination therapy of antifungal drugs has been favored by many scholars. This article summarized treatment mechanism of the combined use of antifungal drugs against invasive fungal infections, and reviewed the combined use of drugs against invasive fungal infections in the central nervous system, lung, blood system, and other parts, providing a reference for the rational use of antibiotics in clinical practice.

R978.5

賀州市科學(xué)研究與技術(shù)開發(fā)計(jì)劃項(xiàng)目(賀科攻1908025)