人工精子激活基礎研究和臨床輔助生殖技術治療中應用最廣泛的精子激活因子為非選擇性磷酸二酯酶(PDE)抑制劑。利用非選擇性PDE抑制劑處理精子能夠全面抑制PDE的活性,通過加強胞內(nèi)環(huán)磷酸腺苷(cAMP)信號來提升精子運動能力?；谌斯ぞ蛹せ畹闹匾饔冒悬cPDE,綜述了3種常用非選擇性PDE抑制劑咖啡因、己酮可可堿和茶堿對人精子運動的激活效應的研究進展,為非選擇性PDE抑制劑用于人工精子激活提供參考。

Non-selective phosphodiesterase (PDE) inhibitor is the most widely used sperm activating factor in basic research of artificial sperm activation and clinical treatment of assisted reproductive technology. Treatment of sperm with non-selective PDE inhibitors can comprehensively inhibit the activity of PDE, and enhance sperm motility by enhancing intracellular cAMP signal. Based on the important target PDE of artificial sperm activation, this paper reviewed the research progress of the activation effect of three commonly used non-selective PDE inhibitors, caffeine, pentoxifylline, and theophylline, on human sperm motility, providing a reference for the application of non-selective phosphodiesterase inhibitors in artificial sperm activation.

R983

柳州市人民醫(yī)院引進高層次人才科研啟動基金項目(LRYGCC202208);柳州市人民醫(yī)院院內(nèi)科研項目(lry202011)