急性腎損傷是以腎功能急性喪失為特征的臨床綜合征,發(fā)病機制復雜。姜黃素可通過穩(wěn)定線粒體功能、減輕腎缺血再灌注損傷、抗炎、抗氧化、調控巨噬細胞功能、抗腎間質纖維化、抗凝血障礙等多種途徑發(fā)揮防治急性腎損傷的作用。總結了姜黃素防治急性腎損傷的作用及其機制,希望為姜黃素的臨床使用提供參考。

Acute renal injury is a clinical syndrome characterized by acute loss of renal function, and its pathogenesis is complex. Curcumin can play a role in prevention and treatment of acute renal injury by stabilizing mitochondrial function, alleviating renal ischemia reperfusion injury, anti-inflammation, anti-oxidation, regulating macrophage function, anti-renal interstitial fibrosis, anticoagulation disorders, and other ways. This article summarized the role and mechanism of curcumin in prevention and treatment of acute renal injury, hoping to provide a reference for the clinical use of curcumin.

R983

石家莊市科學技術研究與發(fā)展計劃項目(191460813)