目的 探討腦安滴丸聯(lián)合長春胺緩釋膠囊治療血栓性腦梗死恢復(fù)期的臨床療效。方法 選取2021年3月—2022年3月在運城市中心醫(yī)院診治的80例血栓性腦梗死恢復(fù)期患者，根據(jù)用藥的差別分為對照組（40例）和治療組（40例）。對照組口服長春胺緩釋膠囊，30 mg/次，2次/d；在對照組基礎(chǔ)上，治療組口服腦安滴丸，20粒/次，2次/d。兩組患者均治療4周。觀察兩組患者臨床療效，比較治療前后兩組患者NIHSS、FMA、AROM、SS-QOL和MBI評分，血清高密度脂蛋白（HDL-C）、低密度脂蛋白膽固醇（LDL-C）、三酰甘油（TG）、總膽固醇（TC）水平，頸總動脈和大腦中動脈的收縮期峰值流速（PSV）、舒張期末流速（EDV）和血管阻力指數(shù)（RI）水平，及血清纖維蛋白原、D-二聚體和血漿比黏度水平。結(jié)果 治療后，對照組臨床有效率為80.00%，明顯低于治療組（97.50%，P＜0.05）。治療后，兩組NIHSS評分明顯下降，而FMA評分、AROM評分、SS-QOL評分和MBI評分明顯升高（P＜0.05），且以治療組評分改善的最為明顯（P＜0.05）。治療后，兩組血清HDL-C水平明顯升高，而LDL-C、TG、TC水平明顯降低（P＜0.05），并且治療組血脂水平明顯好于對照組（P＜0.05）。治療后，兩組頸總動脈、大腦中動脈PSV、EDV明顯升高，而PI明顯降低（P＜0.05），且治療組血流動力學(xué)指標(biāo)明顯好于對照組（P＜0.05）。治療后，兩組血清纖維蛋白原、D-二聚體及血漿比黏度水平明顯降低（P＜0.05），并以治療組降低最為明顯（P＜0.05）。結(jié)論 腦安滴丸聯(lián)合長春胺緩釋膠囊治療血栓性腦梗死恢復(fù)期可有效促進(jìn)患者神經(jīng)功能恢復(fù)，保護(hù)腦神經(jīng)功能，提高患者運動功能，促使患者生活質(zhì)量提高。

Objective To explore the clinical effect of Naoan Dropping Pills combined with vincamine in treatment of thrombotic cerebral infarction in convalescence. Methods Patients (80 cases) with thrombotic cerebral infarction in convalescence in Yuncheng Central Hospital from March 2021 to March 2022 were divided into control (40 cases) and treatment (40 cases) group based on different treatments. Patients in the control group was po administered with Vincamine Sustained Release Capsules, 30 mg/time, twice daily. Patients in the treatment group were po administered with Naoan Dropping Pills on the basis of the control group, 20 pills/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluation was evaluated, and the scores of NIHSS, FMA, AROM, SS-QOL and MBI, the levels of HDL-C, LDL-C, TG and TC, the levels of PSV, EDV and PI in common carotid artery and middle cerebral artery, and the levels of serum fibrinogen, D-dimer and plasma specific viscosity in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the control group was 80.00%, which was significantly lower than that of the treatment group (97.50%, P < 0.05). After treatment, the NIHSS score were significantly decreased, while the FMA score, AROM score, SS-QOL score and MBI score were significantly increased in two groups (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the level of serum HDL-C in two groups were significantly increased, while the levels of LDL-C, TG and TC were significantly decreased (P < 0.05), and the level of blood lipid in the treatment group was significantly better than that in the control group (P < 0.05). After treatment, PSV and EDV of common carotid artery and middle cerebral artery in two groups were significantly increased, while PI were significantly decreased (P < 0.05), and the hemodynamic indexes in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the levels of serum fibrinogen, D-dimer and plasma specific viscosity were significantly decreased in two groups (P < 0.05), especially in the treatment group (P < 0.05). Conclusion Naoan Dropping Pills combined with vinblastine in treatment of thrombotic cerebral infarction in convalescence can effectively promote the recovery of patients’ nerve function, protect brain nerve function, improve patients' motor function and their quality of life.

R971