目的 探討精苓口服液聯(lián)合哌甲酯控釋片治療兒童多動癥的療效和安全性。方法 選取2020年5月—2022年5月成都市婦女兒童中心醫(yī)院收治的80例多動癥患兒，按照隨機數(shù)字表法分為對照組和治療組，每組各40例。對照組口服鹽酸哌甲酯控釋片，1片/次，1次/d。在對照組的基礎(chǔ)上，治療組口服精苓口服液，6～10 mL/次，2次/d。兩組患兒治療30 d。觀察兩組患兒臨床療效，比較治療前后兩組患兒癥狀好轉(zhuǎn)時間，注意力評定量表（SNAP-IV）、多動行為量表（Conners）和兒童智力量表（Raven’s）評分及不良反應情況。結(jié)果 治療后，治療組患者總有效率（97.50%）明顯高于對照組（82.51%，P＜0.05）。治療后，治療組患兒活動過多、情緒不穩(wěn)、注意缺陷、行為沖動等好轉(zhuǎn)時間均明顯短于對照組（P＜0.05）。治療后，兩組SNAP-IV和Conners量表評分明顯降低，而Raven’s評分明顯升高（P＜0.05），且治療組這些量表評分明顯好于對照組（P＜0.05）。治療后，治療組不良反應發(fā)生率（7.50%）明顯低于對照組（17.50%，P＜0.05）。結(jié)論 精苓口服液聯(lián)合哌甲酯治療兒童多動癥效果確切，可有效提高臨床療效，患兒注意力改善顯著，且安全性較好。

Objective To investigate the efficacy and safety of Jingling Oral Liquid combined with methylphenidate in treatment of hyperactivity in children. Methods Children (80 cases) with hyperactivity in Chengdu Women and Children’s Central Hospital from May 2020 to May 2022 were divided into control and treatment group by random number table, and each group had 40 cases. Children in the control group were po administered with Methylphenidate Hydrochloride Controlled Release Tablets, 1 tablet/time, once daily. Children in the treatment group were po administered with Jingling Oral Liquid on the basis of the control group, 6～10 mL/time, twice daily. Children in two groups were treated for 30 d. After treatment, the clinical evaluation was evaluated, and the improvement time of clinical symptoms, the scores of SNAP-IV, Conners and Raven's scale, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.50%) was significantly higher than that of the control group (82.51%, P < 0.05). After treatment, the improvement time of hyperactivity, emotional instability, attention deficit and impulsive behavior in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the scores of SNAP-IV and Conners were significantly decreased, while Raven’s was significantly increased in two groups (P < 0.05), and the scores of these scales in the treatment group were significantly better than those in the control group (P< 0.05). After treatment, the incidence of adverse reactions in the treatment group (7.50%) was significantly lower than that in the control group (17.50%, P < 0.05). Conclusion Jingling Oral Liquid combined with methylphenidate in treatment of hyperactivity in children has definite therapeutic effect, the clinical curative effect can be effectively improved, the attention of children is significantly improved, and the safety is good.

R985

四川省衛(wèi)健委科研基金項目（18PJ291）