目的 探討黃葵膠囊聯(lián)合氫氯噻嗪片治療慢性腎小球腎炎的臨床療效。方法 選取2020年2月—2022年5月開封市中醫(yī)院收治的92例慢性腎小球腎炎患者，按照隨機數(shù)字表法將所有患者分為對照組和治療組，每組各46例。對照組口服氫氯噻嗪片，20 mg/次，3次/d。治療組在對照組基礎(chǔ)上口服黃葵膠囊治療，1粒/次，3次/d。兩組患者連續(xù)治療8周。觀察兩組的臨床療效，比較兩組的腎功能和血清炎性因子水平。結(jié)果 治療后，治療組的總有效率為93.48%，明顯高于對照組的總有效率78.26%，差異具有統(tǒng)計學(xué)意義（P＜0.05）。治療后，兩組24 h尿蛋白定量（24 h Upro）、尿β₂-微球蛋白（β₂-MG）、尿微量白蛋白排泄率（UAER）均顯著降低（P＜0.05）；治療后，治療組患者24 h Upro、β₂-MG、UAER均顯著低于對照組（P＜0.05）。治療后，兩組的血清白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-13（IL-13）水平均顯著降低（P＜0.05），治療組血清IL-6、TNF-α、IL-13水平明顯低于對照組（P＜0.05）。結(jié)論 黃葵膠囊聯(lián)合氫氯噻嗪片治療慢性腎小球腎炎具有較好的臨床療效，能夠改善腎功能，降低炎癥反應(yīng)。

Objective To investigate the clinical effect of huangkui Capsules combined with Hydrochlorothiazide Tablets in treatment of chronic glomerulonephritis. Methods Patients (92 cases) with chronic glomerulonephritis in Kaifeng Hospital of Traditional Chinese Medicine from February 2020 to May 2022 were divided into control and treatment groups according to the random number table method, and each group had 46 cases. Patients in the control group were po administered with Hydrochlorothiazide Tablets, 20 mg/time, three times daily. Patients in the treatment group were po administered with Huangkui Capsules on the basis of the control group, 1 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the renal function and serum inflammatory factor level in two groups were compared. Results After treatment, the total effective rate of the treatment group was 93.48%, which was significantly higher than that of the control group (78.26%) (P < 0.05). After treatment, the levels of 24 h Upro, β₂-MG, and UAER in two groups were significantly decreased (P < 0.05). After treatment, the levels of 24 h Upro, β₂-MG, and UAER in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the serum levels of IL-6, TNF-α, and IL-13 in two groups were significantly decreased (P < 0.05), and the serum levels of IL-6, TNF-α, and IL-13 in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Huangkui Capsules combined with Hydrochlorothiazide Tablets is effective in the treatment of chronic glomerulonephritis, which can improve renal function and reduce inflammatory reaction.

R983

河南省醫(yī)學(xué)科技攻關(guān)計劃（聯(lián)合共建）項目（LHGJ20191045）